Mild gestational hyperglycaemia as a risk factor for metabolic syndrome in pregnancy and adverse perinatal outcomes

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dc.contributor.authorNegrato, Carlos Antonio [UNESP]
dc.contributor.authorJovanovic, Lois
dc.contributor.authorTambascia, Marcos Antonio
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.contributor.authorGeloneze, Bruno
dc.contributor.authorDias, Adriano [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSansum Med Res Inst
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2014-05-20T13:35:32Z
dc.date.available2014-05-20T13:35:32Z
dc.date.issued2008-05-01
dc.description.abstractObjective The aims of this study were to evaluate the prevalence of metabolic syndrome (MS) in a cohort of pregnant women with a wide range of glucose tolerance, pre-pregnancy risk factors for MS during pregnancy and the effects of MS in the occurrence of adverse perinatal outcomes.Research Design and Methods One hundred and thirty six women with positive screening for gestational diabetes (GDM) were classified by two diagnostic methods: glycaemic profile and 100 g oral glucose tolerance test (OGTT) as normoglycaemic, mild gestational hyperglycaemic, GDM, and overt GDM. Markers of insulin resistance were measured between 24-28 and 36th week of gestation, and 6 weeks after delivery.Results The prevalence of MS was 0; 20.0; 23.5 and 36.4% in normoglycaemic, mild hyperglycaemic, GDM and overt GDM groups, respectively. Previous history of GDM with or without insulin use, body mass index (BMI) >= 25, hypertension, family history of diabetes in first-degree relatives, non-Caucasian ethnicity, history of prematurity and polyhydramnios were statistically significant pre-pregnancy predictors for MS in the index pregnancy, that by its turn increased the occurrence of adverse perinatal outcomes (p = 0.01).Conclusions The prevalence of MS increases with the worsening of glucose tolerance and is an independent predictor of adverse perinatal outcomes; impaired glycaemic profile identifies pregnancies with important metabolic abnormalities that are linked to the occurrence of adverse perinatal outcomes even in the presence of a normal OGTT, in patients that are not currently classified as having GDM. Copyright (C) 2008 John Wiley & Sons, Ltd.en
dc.description.affiliationUniv Estadual Paulista, Sch Med Botucatu, São Paulo, Brazil
dc.description.affiliationSansum Med Res Inst, Santa Barbara, CA USA
dc.description.affiliationUniv Estadual Campinas, Sch Med Campinas, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Med Botucatu, São Paulo, Brazil
dc.format.extent324-330
dc.identifierhttp://dx.doi.org/10.1002/dmrr.815
dc.identifier.citationDiabetes-metabolism Research and Reviews. Chichester: John Wiley & Sons Ltd, v. 24, n. 4, p. 324-330, 2008.
dc.identifier.doi10.1002/dmrr.815
dc.identifier.issn1520-7552
dc.identifier.lattes0679387622604743
dc.identifier.lattes6758680388835078
dc.identifier.lattes2966846406062836
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.orcid0000-0001-6895-372X
dc.identifier.urihttp://hdl.handle.net/11449/12241
dc.identifier.wosWOS:000256408200007
dc.language.isoeng
dc.publisherJohn Wiley & Sons Ltd
dc.relation.ispartofDiabetes-metabolism Research and Reviews
dc.relation.ispartofsjr1,807
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpregnancyen
dc.subjecthyperglycaemiaen
dc.subjectgestational diabetesen
dc.titleMild gestational hyperglycaemia as a risk factor for metabolic syndrome in pregnancy and adverse perinatal outcomesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderJohn Wiley & Sons Ltd
unesp.author.lattes2966846406062836[6]
unesp.author.lattes0679387622604743
unesp.author.lattes6758680388835078
unesp.author.orcid0000-0003-4761-4336[4]
unesp.author.orcid0000-0002-9227-832X[7]
unesp.author.orcid0000-0001-6895-372X[6]
unesp.author.orcid0000-0001-6895-372X[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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