Thermal behavior and stability of biodegradable spray-dried microparticles containing triamcinolone

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dc.contributor.authorda Silva-Junior, Arnobio Antonio [UNESP]
dc.contributor.authorde Matos, Jivaldo Rosario
dc.contributor.authorFormariz, Thalita Pedroni [UNESP]
dc.contributor.authorRossanezi, Gustavo [UNESP]
dc.contributor.authorScarpa, Maria Virginia [UNESP]
dc.contributor.authorTabosa do Egito, Eryvaldo Socrates
dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)
dc.date.accessioned2014-05-20T13:24:47Z
dc.date.available2014-05-20T13:24:47Z
dc.date.issued2009-02-23
dc.description.abstractThermal analysis has been widely used for obtaining information about drug-polymer interactions and for pre-formulation studies of pharmaceutical dosage forms. In this work, biodegradable microparticles of Poly (D,L-lactide-co-glycolide) (PLGA) containing triamcinolone (TR) in various drug:polymer ratios were produced by spray drying. The main purpose of this study was to study the effect of the spray-drying process not only on the drug-polymer interactions but also on the stability of microparticles using differential scanning calorimetry (DSC), thermogravimetry (TG) and derivative thermogravimetry (DTG), X-ray analysis (XRD), and infrared spectroscopy (IR). The evaluation of drug-polymer interactions and the pre-formulation studies were assessed using the DSC, TG and DTG, and IR. The quantitative analysis of drugs entrapped in PLGA microparticles was performed by the HPLC method. The results showed high levels of drug-loading efficiency for all used drug: polymer ratio, and the polymorph used for preparing the microparticles was the form B. The DSC and TG/DTG profiles for drug-loaded microparticles were very similar to those for the physical mixtures of the components. Therefore, a correlation between drug content and the structural and thermal properties of drug-loaded PLGA microparticles was established. These data indicate that the spray-drying technique does not affect the physico-chemical stability of the microparticle components. These results are in agreement with the IR analysis demonstrating that no significant chemical interaction occurs between TR and PLGA in both physical mixtures and microparticles. The results of the X-ray analysis are in agreement with the thermal analysis data showing that the amorphous form of TR prevails over a small fraction of crystalline phase of the drug also present in the TR-loaded microparticles. From the pre-formulation studies, we have found that the spray-drying methodology is an efficient process for obtaining TR-loaded PLGA microparticles. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, Dept Quim Fundamental, BR-09500900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal do Rio Grande do Norte (UFRN), Ctr Ciencias Saude, Dept Farm, BR-59010180 Natal, RN, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent45-55
dc.identifierhttp://dx.doi.org/10.1016/j.ijpharm.2008.09.054
dc.identifier.citationInternational Journal of Pharmaceutics. Amsterdam: Elsevier B.V., v. 368, n. 1-2, p. 45-55, 2009.
dc.identifier.doi10.1016/j.ijpharm.2008.09.054
dc.identifier.issn0378-5173
dc.identifier.lattes9114495952533044
dc.identifier.urihttp://hdl.handle.net/11449/7789
dc.identifier.wosWOS:000263847400007
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Pharmaceutics
dc.relation.ispartofjcr3.862
dc.relation.ispartofsjr1,172
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectTriamcinoloneen
dc.subjectPLGA microparticlesen
dc.subjectSpray dryingen
dc.subjectThermal analysisen
dc.subjectX-ray analysisen
dc.subjectThermal stabilityen
dc.titleThermal behavior and stability of biodegradable spray-dried microparticles containing triamcinoloneen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes9114495952533044[7]
unesp.author.orcid0000-0002-0107-9940[7]
unesp.author.orcid0000-0002-2180-3991[6]
unesp.author.orcid0000-0002-7516-1787[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR