Activation of central aα-adrenoceptors mediates salivary gland vasoconstriction

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dc.contributor.authorMoreira, Thiago S.
dc.contributor.authorTakakura, Ana C.
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:17Z
dc.date.available2014-05-27T11:28:17Z
dc.date.issued2013-02-01
dc.description.abstractObjective: Peripheral treatment with the cholinergic agonist pilocarpine increases salivary gland blood flow and induces intense salivation that is reduced by the central injection of moxonidine (aα-adrenoceptors/ imidazoline agonist). In the present study, we investigated the effects of the intracerebroventricular (i.c.v.) injection of pilocarpine alone or combined with moxonidine also injected i.c.v. On submandibular/sublingual gland (SSG) vascular resistance. In addition, the effects of these treatments on arterial pressure, heart rate and on mesenteric and hindlimb vascular resistance were also tested. Design: Male Holtzman rats with stainless steel cannula implanted into lateral ventricle and anaesthetized with urethane + α-chloralose were used. Results: Pilocarpine (500 nmol/1 μl) injected i.c.v. Reduced SSG vascular resistance and increased arterial pressure, heart rate and mesenteric vascular resistance. Contrary to pilocarpine alone, the combination of moxonidine (20 nmol/1 μl) and pilocarpine injected i.c.v. Increased SSG vascular resistance, an effect abolished by the pre-treatment with the α2-adrenoceptor antagonist yohimbine (320 nmol/2 μl). The increase in arterial pressure, heart rate and mesenteric resistance was not modified by the combination of moxonidine and pilocarpine i.c.v. Conclusion: These results suggest that the activation of central α2- adrenoceptors may oppose to the effects of central cholinergic receptor activation in the SSG vascular resistance. © 2012 Elsevier Ltd. All rights reserved.en
dc.description.affiliationDepartment of Physiology and Biophysics Institute of Biomedical Science University of São Paulo, Av. Prof Lineu Prestes, 1524, 05508-000, São Paulo
dc.description.affiliationDepartment of Pharmacology Institute of Biomedical Science University of São Paulo, 05508-900, São Paulo
dc.description.affiliationDepartment of Physiology and Pathology School of Dentistry Sao Paulo State University, 14801-903, Araraquara
dc.description.affiliationUnespDepartment of Physiology and Pathology School of Dentistry Sao Paulo State University, 14801-903, Araraquara
dc.format.extent167-173
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2012.06.017
dc.identifier.citationArchives of Oral Biology, v. 58, n. 2, p. 167-173, 2013.
dc.identifier.doi10.1016/j.archoralbio.2012.06.017
dc.identifier.issn0003-9969
dc.identifier.lattes1023597870118105
dc.identifier.lattes4544450092427426
dc.identifier.scopus2-s2.0-84874117366
dc.identifier.urihttp://hdl.handle.net/11449/74463
dc.identifier.wosWOS:000314199600007
dc.language.isoeng
dc.relation.ispartofArchives of Oral Biology
dc.relation.ispartofjcr2.050
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectα2-Adrenergic receptor
dc.subjectBlood flow and vascular resistance
dc.subjectMoxonidine
dc.subjectParasympathetic
dc.subjectPilocarpine
dc.subjectSalivary gland
dc.subjectRattus
dc.titleActivation of central aα-adrenoceptors mediates salivary gland vasoconstrictionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes1023597870118105
unesp.author.lattes4544450092427426[4]
unesp.author.orcid0000-0002-1395-4036[4]
unesp.author.orcid0000-0003-1167-4441[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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