Green tea glycolic extract-loaded liquid crystal systems: development, characterization and microbiological control

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dc.contributor.authorBernegossi, Jessica [UNESP]
dc.contributor.authorCunha Barbosa, Raquel Maria
dc.contributor.authorRustice, Patricia Maciel
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionPontificia Univ Catolica Campinas
dc.date.accessioned2018-11-26T17:13:54Z
dc.date.available2018-11-26T17:13:54Z
dc.date.issued2016-07-01
dc.description.abstractLiquid crystal systems (LCSs) have interesting cosmetic applications because of their ability to increase the therapeutic efficiency and solubility of active ingredients. The aim of the present research was to develop green tea glycolic extract-loaded LCSs, to characterize and to perform microbiological control. The ternary phase diagram was constructed using polysorbate 20, silicone glycol copolymer (SGC) DC 193((R)), and distilled water with 1.5% glycolic green tea extract. The systems were characterized by polarized light microscopy. Formulations selected were characterized as transparent viscous systems and transparent liquid system indicated mesophases lamellar structure. The results of the microbiological analysis of mesophilic aerobic microorganisms (bacteria and fungi) revealed that the above formulation showed a biologic load < 10 CFU/mL in all samples. In conclusion, liquid crystalline systems that have presented formation of a lamellar mesophases were developed. Furthermore, the formulation and products tested presented the adequate microbiological quality in accordance with official recommendations.en
dc.description.affiliationSao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Med, Sao Paulo, Brazil
dc.description.affiliationPontificia Univ Catolica Campinas, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Pharmaceut Sci, Dept Drugs & Med, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPADC/ FCF (Support Program for Scientific Development at the Faculty of Pharmaceutical Sciences) UNESP, Brazil
dc.description.sponsorshipIdFAPESP: 2010/17037-6
dc.format.extent383-390
dc.identifierhttp://dx.doi.org/10.1590/S1984-82502016000300004
dc.identifier.citationBrazilian Journal Of Pharmaceutical Sciences. Sao Paulo: Univ Sao Paulo, Conjunto Quimicas, v. 52, n. 3, p. 383-390, 2016.
dc.identifier.doi10.1590/S1984-82502016000300004
dc.identifier.fileS1984-82502016000300383.pdf
dc.identifier.issn1984-8250
dc.identifier.scieloS1984-82502016000300383
dc.identifier.urihttp://hdl.handle.net/11449/162264
dc.identifier.wosWOS:000390332400004
dc.language.isoeng
dc.publisherUniv Sao Paulo, Conjunto Quimicas
dc.relation.ispartofBrazilian Journal Of Pharmaceutical Sciences
dc.relation.ispartofsjr0,214
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectCamellia sinensis/glycolic extract
dc.subjectLiquid crystal systems/cosmetic applications
dc.subjectLiquid crystal systems/characterization
dc.subjectLiquid crystal systems/microbiological control
dc.titleGreen tea glycolic extract-loaded liquid crystal systems: development, characterization and microbiological controlen
dc.typeArtigo
dcterms.rightsHolderUniv Sao Paulo, Conjunto Quimicas
unesp.author.orcid0000-0002-6698-0545[4]

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