Streptozotocin-Induced Maternal Hyperglycemia Increases the Expression of Antioxidant Enzymes and Mast Cell Number in Offspring Rat Ventral Prostate

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dc.contributor.authorCamargo, Ana C. L. [UNESP]
dc.contributor.authorDos Santos, Sergio A. A. [UNESP]
dc.contributor.authorRinaldi, Jaqueline C. [UNESP]
dc.contributor.authorConstantino, Flavia B. [UNESP]
dc.contributor.authorColombelli, Ketlin T. [UNESP]
dc.contributor.authorScarano, Wellerson R. [UNESP]
dc.contributor.authorFelisbino, Sergio L. [UNESP]
dc.contributor.authorJustulin, Luis A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T17:16:49Z
dc.date.available2018-11-26T17:16:49Z
dc.date.issued2017-02-01
dc.description.abstractGestational diabetes mellitus (GDM) has increased in recent years. Although the cellular and molecular mechanisms involved in GDM-increased risk factors to offspring remained poorly understood, some studies suggested an association between an increase in oxidative stress induced by maternal hyperglycemia and complications for both mothers and newborns. Here, we investigated the impact of maternal hyperglycemia followed by maternal insulin replacement during lactation on the expression of antioxidant enzymes and mast cell number in offspring ventral prostate (VP) at puberty. Pregnant rats were divided into three groups: control (CT); streptozotocin-induced maternal hyperglycemia (MH); and MH plus maternal insulin replacement during lactation (MHI). Male offspring were euthanized at postnatal day (PND) 60 and the VP was removed and processed for histology and Western blotting analyses. Maternal hyperglycemia delayed prostate maturation, and increased mast cell number catalase (CAT), superoxide dismutase (SOD), glutatione-s-transferase (GST-pi), and cyclooxygenase-2 (Cox-2) expression in the offspring of hyperglycemic dams. Maternal insulin replacement restored VP structure, mast cell number and antioxidant protein expression, except for Cox-2, which remained higher in the MHI group. Thus, an increase in oxidative stress induced by intrauterine hyperglycemia impacts prostate development and maturation, which persists until puberty. The overall improvement of maternal metabolism after insulin administration contributes to the restoration of prostate antioxidant enzymes and secretory function. Taken together, our results highlighted that imbalanced physiological maternal-fetal interaction contributes to the impairment of reproductive performance of the offspring from diabetic mothers. Anat Rec, 300:291-299, 2017. (c) 2016 Wiley Periodicals, Inc.en
dc.description.affiliationSao Paulo State Univ, Inst Biosci, Dept Morphol, Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Inst Biosci, Dept Morphol, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2011/16522-0
dc.description.sponsorshipIdFAPESP: 2012/18100-9
dc.description.sponsorshipIdFAPESP: 2013/19673-5
dc.format.extent291-299
dc.identifierhttp://dx.doi.org/10.1002/ar.23510
dc.identifier.citationAnatomical Record-advances In Integrative Anatomy And Evolutionary Biology. Hoboken: Wiley, v. 300, n. 2, p. 291-299, 2017.
dc.identifier.doi10.1002/ar.23510
dc.identifier.issn1932-8486
dc.identifier.urihttp://hdl.handle.net/11449/162459
dc.identifier.wosWOS:000393921600004
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAnatomical Record-advances In Integrative Anatomy And Evolutionary Biology
dc.relation.ispartofsjr0,766
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectventral prostate
dc.subjectmaternal hyperglycemia
dc.subjectmast cell
dc.subjectantioxidant enzymes
dc.titleStreptozotocin-Induced Maternal Hyperglycemia Increases the Expression of Antioxidant Enzymes and Mast Cell Number in Offspring Rat Ventral Prostateen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell

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