Evaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella

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dc.contributor.authorZalewski, Cynthia A.
dc.contributor.authorPassero, Luiz Felipe D.
dc.contributor.authorMelo, Alexis S. R. B. [UNESP]
dc.contributor.authorCorbett, Carlos Eduardo P.
dc.contributor.authorLaurenti, Marcia D.
dc.contributor.authorToyama, Marcos H. [UNESP]
dc.contributor.authorToyama, Daniela O.
dc.contributor.authorRomoff, Paulete
dc.contributor.authorFavero, Oriana A.
dc.contributor.authorLago, Joao Henrique G.
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Presbiteriana Mackenzie
dc.date.accessioned2014-05-20T13:12:24Z
dc.date.available2014-05-20T13:12:24Z
dc.date.issued2011-06-01
dc.description.abstractContext: Species of Baccharis exhibit antibiotic, antiseptic, and wound-healing properties, and have been used in the traditional medicine of South America for the treatment of inflammation, headaches, diabetes, and hepatobiliary disorders.Objective: To investigate the anti-inflammatory activity of organic phases from EtOH extract of the aerial parts of Baccharis uncinella DC (Asteraceae).Materials and methods: The crude EtOH extract from the aerial parts of B. uncinella was subjected to partition procedures and the corresponding CH(2)Cl(2) and EtOAc phases were subjected to several chromatographic separation procedures. Thus, these phases and their purified compounds were assayed for evaluation of anti-inflammatory activity.Results: The CH(2)Cl(2) phase from EtOH extract from B. uncinella contained two triterpenoids (oleanolic and ursolic acids) and one flavonoid (pectolinaringenin), whereas the respective EtOAc phase showed to be composed mainly by two phenylpropanoid derivatives (caffeic and ferulic acids). The CH(2)Cl(2) and EtOAc phases as well as their isolated compounds exhibited anti-inflammatory effects against inflammatory reactions induced by phospholipase A2 (from Crotalus durissus terrificus venom) and by carrageenan.Discussion and conclusion: The results suggested that the components obtained from partition phases of EtOH extract of B. uncinella could represent lead molecules for the development of anti-inflammatory agents. Additionally, the results confirmed the use of Baccharis genus in the traditional medicine of South America for the treatment of inflammation and other heath disorders. To date, the present work describes for the first time the anti-inflammatory effects of compounds isolated from B. uncinella.en
dc.description.affiliationUniv Fed São Paulo, Dept Ciencias Exatas & Terra, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Patol, Lab Patol Molestias Infecciosas LIM 50, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista Julio de Mesquito Filho, Sao Vicente, SP, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Ctr Ciencias Humanidades, Lab Quim Prod Nat, São Paulo, Brazil
dc.description.affiliationUniv Presbiteriana Mackenzie, Ctr Ciencias Biol & Saude, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio de Mesquito Filho, Sao Vicente, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipMackPesquisa
dc.description.sponsorshipLIM-50 HC-FMUSP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent602-607
dc.identifierhttp://dx.doi.org/10.3109/13880209.2010.537828
dc.identifier.citationPharmaceutical Biology. London: Informa Healthcare, v. 49, n. 6, p. 602-607, 2011.
dc.identifier.doi10.3109/13880209.2010.537828
dc.identifier.issn1388-0209
dc.identifier.urihttp://hdl.handle.net/11449/377
dc.identifier.wosWOS:000290404200008
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofPharmaceutical Biology
dc.relation.ispartofjcr1.918
dc.relation.ispartofsjr0,563
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSecretory phospholipase A2 (sPLA2)en
dc.subjectanti-inflammatoryen
dc.subjecttriterpenesen
dc.subjectphenolic compoundsen
dc.titleEvaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinellaen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderInforma Healthcare
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept

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Artigos - Ciências Biológicas - São Vicente