In vitro basal and metabolism-mediated cytotoxicity of flavonoids

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dc.contributor.authorSoares, VCG
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.authorRaddi, MSG
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:33Z
dc.date.available2014-05-20T13:24:33Z
dc.date.issued2006-06-01
dc.description.abstractThe purpose of this study was to compare the basal cytotoxicity and metabolism-mediated cytotoxicity of kaempferol, quercetin and rutin. McCoy cells were exposed to various concentrations of the flavonols with and without the S9 system. The neutral red uptake assay was used to determine viability after 24 h at 35-37 degrees C. Dose-response curves were established for each flavonol in the presence and absence of external metabolizing systems. Kaempferol and quercetin were cytotoxic and provoked a dose-dependent decrease in cell viability, without the S9 system. The hepatic S9 microsomal fraction metabolized these compounds to less cytotoxic metabolites. In contrast, rutin at 500 mu g/ml failed to produce any overt signs of toxicity in either assay. (c) 2005 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Ciências Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Quim Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Ciências Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Quim Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.format.extent835-838
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2005.11.006
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 44, n. 6, p. 835-838, 2006.
dc.identifier.doi10.1016/j.fct.2005.11.006
dc.identifier.issn0278-6915
dc.identifier.lattes7501930236496670
dc.identifier.urihttp://hdl.handle.net/11449/7651
dc.identifier.wosWOS:000238552600006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectflavonolspt
dc.subjectcytotoxicitypt
dc.subjectS9pt
dc.subjectmetabolic activationpt
dc.titleIn vitro basal and metabolism-mediated cytotoxicity of flavonoidsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7501930236496670
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Ciências Biológicas - FCFAR
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