The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags

Página do item simplificado
dc.contributor.authorBrentani, H.
dc.contributor.authorCaballero, O. L.
dc.contributor.authorCamargo, A. A.
dc.contributor.authorda Silva, A. M.
dc.contributor.authorda Silva, W. A.
dc.contributor.authorNeto, E. D.
dc.contributor.authorGrivet, M.
dc.contributor.authorGruber, A.
dc.contributor.authorGuimaraes, PEM
dc.contributor.authorHide, W.
dc.contributor.authorIseli, C.
dc.contributor.authorJongeneel, C. V.
dc.contributor.authorKelso, J.
dc.contributor.authorNagai, M. A.
dc.contributor.authorOjopi, EPB
dc.contributor.authorOsorio, E. C.
dc.contributor.authorReis, EMR
dc.contributor.authorRiggins, G. J.
dc.contributor.authorSimpson, AJG
dc.contributor.authorde Souza, S.
dc.contributor.authorStevenson, B. J.
dc.contributor.authorStrausberg, R. L.
dc.contributor.authorTajara, E. H.
dc.contributor.authorVerjovski-Almeida, S.
dc.contributor.authorAcencion, M. L.
dc.contributor.authorBengtsono, M. H.
dc.contributor.authorBettonip, F.
dc.contributor.authorBodmerq, W. F.
dc.contributor.authorBrionesr, MRS
dc.contributor.authorCamargos, L. P.
dc.contributor.authorCaveneet, W.
dc.contributor.authorCeruttiu, J. M.
dc.contributor.authorCoelho Andradev, L. E.
dc.contributor.authorCosta dos Santosn, P. C.
dc.contributor.authorCostaw, MCR
dc.contributor.authorda Silvaw, I. T.
dc.contributor.authorEsteciox, MRH
dc.contributor.authorFerreiraw, K. S.
dc.contributor.authorFurnarit, F. B.
dc.contributor.authorFaria, M.
dc.contributor.authorGalantep, PAF
dc.contributor.authorGuimaraesy, G. S.
dc.contributor.authorHolandaw, A. J.
dc.contributor.authorKimuraz, E. T.
dc.contributor.authorLeerkesp, M. R.
dc.contributor.authorXin, L. A.
dc.contributor.authorMacielu, RMB
dc.contributor.authorMartinsbb, EAL
dc.contributor.authorMassirero, K. B.
dc.contributor.authorMelor, ASA
dc.contributor.authorMestrinercc, C. A.
dc.contributor.authorMiraccan, E. C.
dc.contributor.authorMirandas, L. L.
dc.contributor.authorNobregadd, F. G.
dc.contributor.authorOliveirap, P. S.
dc.contributor.authorPaquolaee, ACM
dc.contributor.authorPandolficc, JRC
dc.contributor.authorPardiniff, MIDC
dc.contributor.authorPassettip, F.
dc.contributor.authorQuackenbushgg, J.
dc.contributor.authorSchnabelr, B.
dc.contributor.authorSogayaro, M. C.
dc.contributor.authorSouzap, J. E.
dc.contributor.authorValentinicc, SR
dc.contributor.authorZaiatsp, A. C.
dc.contributor.authorAmaralx, E. J.
dc.contributor.authorArnaldiu, LAT
dc.contributor.authorde Araujow, A. G.
dc.contributor.authorde Bessan, S. A.
dc.contributor.authorBicknellq, D. C.
dc.contributor.authorde Camaroy, MER
dc.contributor.authorCarrarop, D. M.
dc.contributor.authorCarrerhh, H.
dc.contributor.authorCarvalhop, A. F.
dc.contributor.authorColino, C.
dc.contributor.authorCostaii, F.
dc.contributor.authorCurcioz, C.
dc.contributor.authorda Silvaw, IDCG
dc.contributor.authorda Silvav, N. P.
dc.contributor.authorDellamanop, M.
dc.contributor.authorEl-Dorrykk, H.
dc.contributor.authorEspreaficoll, E. M.
dc.contributor.authorFerreirakk, AJS
dc.contributor.authorFerreiraw, C. A.
dc.contributor.authorFortesmm, MAHZ
dc.contributor.authorGamann, A. H.
dc.contributor.authorGiannella-Netomm, D.
dc.contributor.authorGiannellamm, MLCC
dc.contributor.authorGiorgimm, R. R.
dc.contributor.authorGoldmanoo, G. H.
dc.contributor.authorGoldmanpp, MHS
dc.contributor.authorHackely, C.
dc.contributor.authorHobb, P. L.
dc.contributor.authorKimuraqq, E. M.
dc.contributor.authorKowalskirr, L. P.
dc.contributor.authorKriegerss, J. E.
dc.contributor.authorLeitebb, LCC
dc.contributor.authorLopesrr, A.
dc.contributor.authorLunamm, AMSC
dc.contributor.authorMackaytt, A.
dc.contributor.authorMarin, SKN
dc.contributor.authorMarquesw, A. A.
dc.contributor.authorMartinsp, W. K.
dc.contributor.authorMontagninirr, A.
dc.contributor.authorNetorr, M. M.
dc.contributor.authorNascimentobb, ALTO
dc.contributor.authorNevilleuu, A. M.
dc.contributor.authorNobregadd, M. P.
dc.contributor.authorO'Harett, M. J.
dc.contributor.authorOtsukavv, A. Y.
dc.contributor.authorde Melop, AIR
dc.contributor.authorPaco-Larsonww, M. L.
dc.contributor.authorPereiraii, G. G.
dc.contributor.authorPereira da Silvav, N.
dc.contributor.authorPesquerojj, J. B.
dc.contributor.authorPessoajj, J. G.
dc.contributor.authorRahal, Paula [UNESP]
dc.contributor.authorRainhoxx, C. A.
dc.contributor.authorRodriguesyy, V
dc.contributor.authorRogatto, Silvia Regina [UNESP]
dc.contributor.authorRomanozz, C. M.
dc.contributor.authorRomeirox, J. G.
dc.contributor.authorRossirr, B. M.
dc.contributor.authorRusticcin, M.
dc.contributor.authorde Sayy, R. G.
dc.contributor.authorSant' Annaqq, S. C.
dc.contributor.authorSarmazox, M. L.
dc.contributor.authorde Lima e Silvay, T. C.
dc.contributor.authorSoaresrr, F. A.
dc.contributor.authorSonatiqq, M. D.
dc.contributor.authorSousall, J. D.
dc.contributor.authorQueirozy, D.
dc.contributor.authorValenteww, V
dc.contributor.authorVettorep, A. L.
dc.contributor.authorVillanovavv, F. E.
dc.contributor.authorZagow, M. A.
dc.contributor.authorZalcbergp, H.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLudwig Inst Canc Res
dc.contributor.institutionNCI
dc.contributor.institutionDuke Univ
dc.contributor.institutionUniv Western Cape
dc.contributor.institutionCtr Estudo Telecomun PUC
dc.date.accessioned2014-05-20T15:29:43Z
dc.date.available2014-05-20T15:29:43Z
dc.date.issued2003-11-11
dc.description.abstractWhereas genome sequencing defines the genetic potential of an organism, transcript sequencing defines the utilization of this potential and links the genome with most areas of biology. To exploit the information within the human genome in the fight against cancer, we have deposited some two million expressed sequence tags (ESTs) from human tumors and their corresponding normal tissues in the public databases. The data currently define approximate to23,500 genes, of which only approximate to1,250 are still represented only by ESTs. Examination of the EST coverage of known cancer-related (CR) genes reveals that <1% do not have corresponding ESTs, indicating that the representation of genes associated with commonly studied tumors is high. The careful recording of the origin of all ESTs we have produced has enabled detailed definition of where the genes they represent are expressed in the human body. More than 100,000 ESTs are available for seven tissues, indicating a surprising variability of gene usage that has led to the discovery of a significant number of genes with restricted expression, and that may thus be therapeutically useful. The ESTs also reveal novel nonsynonymous germline variants (although the one-pass nature of the data necessitates careful validation) and many alternatively spliced transcripts. Although widely exploited by the scientific community, vindicating our totally open source policy, the EST data generated still provide extensive information that remains to be systematically explored, and that may further facilitate progress toward both the understanding and treatment of human cancers.en
dc.description.affiliationUniv São Paulo, Lab Genet Mol Canc, Dept Radiol, BR-05403010 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Bioquim, Inst Quim, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Biol, Inst Biociencias, BR-15054 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationLudwig Inst Canc Res, BR-01509010 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Patol, Fac Med Vet & Zootecn, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fdn Hemocentro Ribeirao Preto, Fac Med Ribeirao Preto, BR-14051140 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Neurosci Lab, Inst Psiquiatria, Fac Med, BR-05403010 São Paulo, Brazil
dc.description.affiliationNCI, Bethesda, MD 20892 USA
dc.description.affiliationDuke Univ, Med Ctr, Durham, NC 27710 USA
dc.description.affiliationUniv Western Cape, S African Natl Bioinformat Inst, ZA-7535 Bellville, South Africa
dc.description.affiliationLudwig Inst Canc Res, Off Informat Technol, CH-1066 Epalinges, Switzerland
dc.description.affiliationCtr Estudo Telecomun PUC, BR-22453900 Rio de Janeiro, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Biol, Inst Biociencias, BR-15054 Sao Jose do Rio Preto, SP, Brazil
dc.format.extent13418-13423
dc.identifierhttp://dx.doi.org/10.1073/pnas.1233632100
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. Washington: Natl Acad Sciences, v. 100, n. 23, p. 13418-13423, 2003.
dc.identifier.doi10.1073/pnas.1233632100
dc.identifier.issn0027-8424
dc.identifier.lattes7991082362671212
dc.identifier.orcid0000-0001-5693-6148
dc.identifier.urihttp://hdl.handle.net/11449/39236
dc.identifier.wosWOS:000186573700056
dc.language.isoeng
dc.publisherNatl Acad Sciences
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America
dc.relation.ispartofjcr9.504
dc.relation.ispartofsjr6,092
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleThe generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tagsen
dc.typeArtigo
dcterms.licensehttp://www.pnas.org/site/misc/authorlicense.pdf
dcterms.rightsHolderNatl Acad Sciences
unesp.author.lattes7991082362671212[117]
unesp.author.orcid0000-0001-9249-4922[5]
unesp.author.orcid0000-0002-0728-4937[14]
unesp.author.orcid0000-0002-3922-1906[12]
unesp.author.orcid0000-0002-9556-3070[17]
unesp.author.orcid0000-0002-8621-3271[10]
unesp.author.orcid0000-0001-5192-4682[1]
unesp.author.orcid0000-0002-2603-2057[23]
unesp.author.orcid0000-0002-6076-9597[3]
unesp.author.orcid0000-0002-6356-2401[24]
unesp.author.orcid0000-0002-2296-2863[11]
unesp.author.orcid0000-0001-5824-5199[15]
unesp.author.orcid0000-0001-8093-2278[8]
unesp.author.orcid0000-0002-7530-600X[9]
unesp.author.orcid0000-0001-5693-6148[117]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

Arquivos

Licença do Pacote
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Biologia - IBILCE