Impact of timing of the anorexigen sibutramine administration on reproductive end-points of male rats

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dc.contributor.authorBorges, Cibele S. [UNESP]
dc.contributor.authorSilva, Patrícia V. [UNESP]
dc.contributor.authorLozano, Ana Flávia Q. [UNESP]
dc.contributor.authorMissassi, Gabriela [UNESP]
dc.contributor.authorSilva, Raquel F. [UNESP]
dc.contributor.authorAnselmo-Franci, Janete A.
dc.contributor.authorKempinas, Wilma G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2020-12-12T02:46:16Z
dc.date.available2020-12-12T02:46:16Z
dc.date.issued2020-01-01
dc.description.abstractSibutramine is a non-selective serotonin-norepinephrine reuptake inhibitor orally administered for weight loss. In a previous study, we showed pharmacological mechanisms involved in the reduction of sperm quality and fertility of rats exposed for 30 days to this anorexigen in the light phase of the light-dark (l/d) cycle. It is already known that rodents are nightlife animals, with higher metabolic activity during the dark phase than in the light phase of the light-dark (l/d) cycle. Thus, the present study aimed to investigate whether the deleterious effects on reproductive parameters after sibutramine administration would be enhanced after a shorter period of exposure during the dark phase of the l/d cycle. For this, adult male Wistar rats were treated with sibutramine (10 mg/kg/d) or vehicle for 15 days during the dark phase of the l/d cycle. Sibutramine treatment decreased final body and reproductive organ weights, as well as serum testosterone levels. Sperm transit time through the epididymis was accelerated, and sperm concentration and motility were diminished in the sibutramine-exposed rats. The decrease in sperm concentration was also verified in the epididymal histological sections. In conclusion, the deleterious effects of sibutramine on reproductive parameters of male rats were enhanced when the exposure occurred in the dark phase of the l/d cycle, even after a short exposure duration. Our results reinforce the impact of timing on drug therapeutic action.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biosciences UNESP - São Paulo State University
dc.description.affiliationDepartment of Morphology Stomatology and Physiology USP – University of São Paulo
dc.description.affiliationUnespDepartment of Structural and Functional Biology Institute of Biosciences UNESP - São Paulo State University
dc.identifierhttp://dx.doi.org/10.1111/bcpt.13467
dc.identifier.citationBasic and Clinical Pharmacology and Toxicology.
dc.identifier.doi10.1111/bcpt.13467
dc.identifier.issn1742-7843
dc.identifier.issn1742-7835
dc.identifier.scopus2-s2.0-85088261713
dc.identifier.urihttp://hdl.handle.net/11449/201959
dc.language.isoeng
dc.relation.ispartofBasic and Clinical Pharmacology and Toxicology
dc.sourceScopus
dc.subjectchronopharmacology
dc.subjectdrug toxicity
dc.subjectmale reproductive tract
dc.subjectrat
dc.subjectsibutramine
dc.titleImpact of timing of the anorexigen sibutramine administration on reproductive end-points of male ratsen
dc.typeArtigo

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