Tissue tolerance of diclofenac sodium encapsulated in liposomes after intramuscular administration

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dc.contributor.authorLima, E. M.
dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2014-05-20T15:29:36Z
dc.date.available2014-05-20T15:29:36Z
dc.date.issued2002-01-01
dc.description.abstractIn this work the effect of the encapsulation of diclofenac sodium within liposomes on the reduction of the myotoxicity after intramuscular administration in rats was studied. Diclofenac sodium was encapsulated in small unilamellar liposomes obtained from phosphatidylcholine, cholesterol, and a-tocopherol (40:10:0.04 mM), and administered by intramuscular injection in the quadriceps femoral muscle of male Wistar rats. After a single dose of 0.2 mg diclofenac formulations the local tissue damage was assessed by plasma creatine kinase (CPK) activity and histological analysis. It was demonstrated that formulations containing free diclofenac produced a higher increase in CPK activity, while those encapsulated in liposomes exhibited CPK activity similar to the control groups. Histopathological analysis of local muscle tissue performed on the third and seventh days following the injection showed intense cellular damage when free drug solution was used, while encapsulation in liposome protected the tissue against the local tissue inflammation.en
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Dept Farm & Medicamentos, BR-14801902 São Paulo, Brazil
dc.description.affiliationUFG, Fac Farm, BR-74605220 Goiania, Go, Brazil
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Dept Farm & Medicamentos, BR-14801902 São Paulo, Brazil
dc.format.extent673-680
dc.identifierhttp://dx.doi.org/10.1081/DDC-120003858
dc.identifier.citationDrug Development and Industrial Pharmacy. New York: Marcel Dekker Inc., v. 28, n. 6, p. 673-680, 2002.
dc.identifier.doi10.1081/DDC-120003858
dc.identifier.issn0363-9045
dc.identifier.lattes9114495952533044
dc.identifier.urihttp://hdl.handle.net/11449/39147
dc.identifier.wosWOS:000176824400006
dc.language.isoeng
dc.publisherMarcel Dekker Inc
dc.relation.ispartofDrug Development and Industrial Pharmacy
dc.relation.ispartofjcr1.883
dc.relation.ispartofsjr0,519
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcreatine kinasept
dc.subjectdiclofenac sodiumpt
dc.subjectliposomespt
dc.subjectmyotoxicitypt
dc.titleTissue tolerance of diclofenac sodium encapsulated in liposomes after intramuscular administrationen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/page/resources/authors
dcterms.rightsHolderMarcel Dekker Inc
unesp.author.lattes9114495952533044[2]
unesp.author.orcid0000-0003-1231-5803[1]
unesp.author.orcid0000-0002-0107-9940[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR