The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity

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dc.contributor.authorMoreto, Fernando [UNESP]
dc.contributor.authorOliveira, Erick P. de [UNESP]
dc.contributor.authorManda, Rodrigo M. [UNESP]
dc.contributor.authorBurini, Roberto Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)
dc.date.accessioned2014-12-03T13:07:03Z
dc.date.available2014-12-03T13:07:03Z
dc.date.issued2014-01-01
dc.description.abstractThis study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 +/- 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), gamma-glutamyltransferase (gamma-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and gamma-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.en
dc.description.affiliationSao Paulo State Univ, Botucatu Sch Med, Ctr Nutr & Exercise Metab CeMENutri, Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Uberlandia, Sch Med, BR-38400 Uberlandia, MG, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Botucatu Sch Med, Ctr Nutr & Exercise Metab CeMENutri, Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent7
dc.identifierhttp://dx.doi.org/10.1155/2014/505368
dc.identifier.citationOxidative Medicine And Cellular Longevity. New York: Hindawi Publishing Corporation, 7 p., 2014.
dc.identifier.doi10.1155/2014/505368
dc.identifier.fileWOS000338551500001.pdf
dc.identifier.issn1942-0900
dc.identifier.lattes2287552780901172
dc.identifier.urihttp://hdl.handle.net/11449/111198
dc.identifier.wosWOS:000338551500001
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofOxidative Medicine and Cellular Longevity
dc.relation.ispartofjcr4.936
dc.relation.ispartofsjr1,558
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleThe Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicityen
dc.typeArtigo
dcterms.rightsHolderHindawi Publishing Corporation
unesp.author.lattes2287552780901172
unesp.author.orcid0000-0002-4028-0014[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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