Developmental programming of the female neuroendocrine system by steroids

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dc.contributor.authorAbruzzese, Giselle Adriana
dc.contributor.authorCrisosto, Nicolás
dc.contributor.authorDe Grava Kempinas, Wilma [UNESP]
dc.contributor.authorSotomayor-Zárate, Ramón
dc.contributor.institutionUniversidad de Buenos Aires (UBA)
dc.contributor.institutionUniversity of Chile
dc.contributor.institutionClínica Las Condes
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidad de Valparaíso
dc.date.accessioned2018-12-11T17:38:18Z
dc.date.available2018-12-11T17:38:18Z
dc.date.issued2018-01-01
dc.description.abstractDevelopmental programming refers to processes that occur during early life that may have long-term consequences, modulating adult health and disease. Complex diseases, such as diabetes, cancer and cardiovascular disease, have a high prevalence in different populations, are multifactorial, and may have a strong environmental component. The environment interacts with organisms, affecting their behaviour, morphology and physiology. This interaction may induce permanent or long-term changes, and organisms may be more susceptible to environmental factors during certain developmental stages, such as the prenatal and early postnatal periods. Several factors have been identified as responsible for inducing the reprogramming of various reproductive and nonreproductive tissues. Among them, both natural and synthetic steroids, such as endocrine disruptors, are known to have either detrimental or positive effects on organisms depending on the dose of exposure, stage of development and biological sexual background. The present review focuses on the action of steroids and endocrine disruptors as agents involved in developmental programming and on their modulation and effects on female neuroendocrine functions.en
dc.description.affiliationLaboratorio de Fisio-patología Ovárica Centro de Estudios Farmacológicos y Botánicos (CEFYBO) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) Facultad de Medicina Universidad de Buenos Aires (UBA)
dc.description.affiliationEndocrinology and Metabolism Laboratory West Division School of Medicine University of Chile
dc.description.affiliationEndocrinology Unit Clínica Las Condes
dc.description.affiliationLaboratory of Reproductive and Developmental Biology and Toxicology Department of Morphology Institute of Biosciences Universidade Estadual Paulista-UNESP
dc.description.affiliationLaboratorio de Neuroquímica y Neurofarmacología Centro de Neurobiología y Fisiopatología Integrativa Instituto de Fisiología Facultad de Ciencias Universidad de Valparaíso
dc.description.affiliationUnespLaboratory of Reproductive and Developmental Biology and Toxicology Department of Morphology Institute of Biosciences Universidade Estadual Paulista-UNESP
dc.identifierhttp://dx.doi.org/10.1111/jne.12632
dc.identifier.citationJournal of Neuroendocrinology.
dc.identifier.doi10.1111/jne.12632
dc.identifier.issn1365-2826
dc.identifier.issn0953-8194
dc.identifier.scopus2-s2.0-85052369525
dc.identifier.urihttp://hdl.handle.net/11449/180133
dc.language.isoeng
dc.relation.ispartofJournal of Neuroendocrinology
dc.relation.ispartofsjr1,554
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectdevelopmental programming
dc.subjectendocrine disruptors
dc.subjectglucocorticoids
dc.subjectgonadal steroids
dc.titleDevelopmental programming of the female neuroendocrine system by steroidsen
dc.typeArtigo
unesp.author.orcid0000-0003-3498-7010[1]
unesp.author.orcid0000-0002-1239-5367[4]

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