Clinical and microbiological effects of photodynamic therapy associated with nonsurgical periodontal treatment. A 6-month follow-up

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dc.contributor.authorTheodoro, Letícia Helena [UNESP]
dc.contributor.authorSilva, Simoni Paro
dc.contributor.authorPires, Juliana Rico
dc.contributor.authorGarcia Soares, Glaucia Helena
dc.contributor.authorFarias Pontes, Ana Emilia
dc.contributor.authorZuza, Elizangela Partata
dc.contributor.authorSpolidório, Denise Madalena Palomari [UNESP]
dc.contributor.authorCorrea de Toledo, Benedicto Egbert
dc.contributor.authorGarcia, Valdir Gouveia [UNESP]
dc.contributor.institutionUniv Ctr Educ Fdn Barretos UNIFEB
dc.contributor.institutionEduc Fdn Barretos UNIFEB
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:29:46Z
dc.date.accessioned2014-05-20T13:43:26Z
dc.date.available2013-09-30T18:29:46Z
dc.date.available2014-05-20T13:43:26Z
dc.date.issued2012-07-01
dc.description.abstractExperimental studies in animals and in vitro have shown the usefulness of photodynamic therapy (PDT) as an adjunct to periodontal treatment. The aim of this study was to evaluate the long-term clinical and microbiological effects of PDT associated with nonsurgical periodontal treatment. Three sites in each of 33 patients with chronic periodontitis were randomly allocated in a split-mouth design to a treatment group: (1) scaling and root planing (SRP group); (2) SRP and irrigation with toluidine blue O (TBO group); and (3) SRP, irrigation with TBO and low-level laser irradiation (PDT group). Clinical parameters including visible plaque index, bleeding gingival index, bleeding on probing, probing depth, gingival recession and clinical attachment level were measured at baseline, and after 60, 90 and 180 days. Additionally, subgingival plaque samples were collected for microbiological analysis by PCR. Intergroup and intragroup statistical analyses were performed. All treatment groups showed an improvement in all clinical parameters, and a significant reduction in the proportion of sites positive for periodontopathogens at 60, 90 and 180 days compared to baseline (p < 0.05). None of the periodontal parameters showed a significant difference among the groups (p > 0.05). At 180 days, PDT treatment led to a significant reduction in the percentage of sites positive for all bacteria compared to SRP alone (p < 0.05). Within the limits of this study it may be concluded that PDT as an adjunct to periodontal treatment produced statistically significant reductions in some of the key periodontal pathogens but produced no statistically significant benefit in terms of clinical outcome.en
dc.description.affiliationUniv Ctr Educ Fdn Barretos UNIFEB, BR-14783226 Barretos, SP, Brazil
dc.description.affiliationEduc Fdn Barretos UNIFEB, Sch Dent, Dept Periodontol, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Physiol & Pathol, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Div Periodont, Dept Surg, Grp Study & Res Laser Dent GEPLO, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Integrated Clin, Div Periodont, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Physiol & Pathol, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Div Periodont, Dept Surg, Grp Study & Res Laser Dent GEPLO, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Integrated Clin, Div Periodont, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/039001
dc.format.extent687-693
dc.identifierhttp://dx.doi.org/10.1007/s10103-011-0942-x
dc.identifier.citationLasers In Medical Science. London: Springer London Ltd, v. 27, n. 4, p. 687-693, 2012.
dc.identifier.doi10.1007/s10103-011-0942-x
dc.identifier.issn0268-8921
dc.identifier.lattes4774447118127346
dc.identifier.lattes4068921369233125
dc.identifier.urihttp://hdl.handle.net/11449/15155
dc.identifier.wosWOS:000305274100001
dc.language.isoeng
dc.publisherSpringer London Ltd
dc.relation.ispartofLasers in Medical Science
dc.relation.ispartofjcr1.949
dc.relation.ispartofsjr0,713
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectChronic periodontitisen
dc.subjectPhotodynamic therapyen
dc.subjectPeriodontal disease/therapyen
dc.subjectRandomized controlled trialen
dc.titleClinical and microbiological effects of photodynamic therapy associated with nonsurgical periodontal treatment. A 6-month follow-upen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer London Ltd
unesp.author.orcid0000-0003-2376-1024[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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Artigos - Fisiologia e Patologia - FOAR
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