Immunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide production

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dc.contributor.authorCarlos, Iracilda Z. [UNESP]
dc.contributor.authorCarli, Camila B. A. [UNESP]
dc.contributor.authorMaia, Danielle C. G. [UNESP]
dc.contributor.authorBenzatti, Fernanda P. [UNESP]
dc.contributor.authorLopes, Flavia C. M. [UNESP]
dc.contributor.authorRoese, Fernanda M.
dc.contributor.authorWatanabe, Márcio
dc.contributor.authorMicheletti, Ana C.
dc.contributor.authorSantos, Lourdes Campaner dos [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorHonda, Neli K.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.date.accessioned2014-05-27T11:23:59Z
dc.date.available2014-05-27T11:23:59Z
dc.date.issued2009-10-01
dc.description.abstractThe effects of isolated compounds from Brazilian lichens and their derivatives on H 2O 2 and NO production were studied using murine macrophages as a part of an attempt to understand their possible immunomodulatory properties. The compound cytotoxicity was studied using MTT assay. Macrophage stimulation was evaluated by the determination of NO (Griess assay) and H 2O 2 (horseradish peroxidase/phenol red) in supernatants of peritoneal macrophage cultures of Swiss mice. This research demonstrated stimulatory activities of some phenolic compounds isolated from lichens and their derivatives on H 2O 2 and NO production. Structure-activity relationships suggest several synthetic directions for further improvement of immunological activity.en
dc.description.affiliationDepartament of Clinical Analysis Faculdade de Ciências Farmacêuticas de Araraquara São Paulo State University, Post Office Box 502, Araraquara-SP 14801-902
dc.description.affiliationDepartament of Chemistry Universidade Federal do Mato Grosso do Sul, Campo Grande-MS
dc.description.affiliationDepartment of Organic Chemistry Instituto de Química de Araraquara São Paulo State University, Post Office Box 355, Araraquara-SP 14801-970
dc.description.affiliationUnespDepartament of Clinical Analysis Faculdade de Ciências Farmacêuticas de Araraquara São Paulo State University, Post Office Box 502, Araraquara-SP 14801-902
dc.description.affiliationUnespDepartment of Organic Chemistry Instituto de Química de Araraquara São Paulo State University, Post Office Box 355, Araraquara-SP 14801-970
dc.format.extent847-852
dc.identifierhttp://dx.doi.org/10.1590/S0102-695X2009000600009
dc.identifier.citationBrazilian Journal of Pharmacognosy, v. 19, n. 4, p. 847-852, 2009.
dc.identifier.doi10.1590/S0102-695X2009000600009
dc.identifier.file2-s2.0-77949514631.pdf
dc.identifier.issn0102-695X
dc.identifier.lattes3538253640602977
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.scieloS0102-695X2009000600009
dc.identifier.scopus2-s2.0-77949514631
dc.identifier.urihttp://hdl.handle.net/11449/71177
dc.identifier.wosWOS:000275593200009
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Pharmacognosy
dc.relation.ispartofjcr1.596
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectHydrogen peroxide
dc.subjectLichens
dc.subjectMacrophages
dc.subjectNitric oxide
dc.subjectPhenolic compounds
dc.subject8' o n propyl norstitic acid
dc.subject9' o ethyl norstitic acid
dc.subject9' o ethyl protocetraric acid
dc.subject9' o iso propyl protocetraric acid
dc.subject9' o methyl protocetraric acid
dc.subject9' o n butyl protocetraric acid
dc.subject9' o n hexyl protocetraric acid
dc.subject9' o n pentyl protocetraric acid
dc.subject9' o n propyl protocetraric acid
dc.subject9' o sec butyl protocetraric acid
dc.subject9' o terc butyl protocetraric acid
dc.subjectcomprotocetraric acid
dc.subjecthydrogen peroxide
dc.subjectimmunostimulating agent
dc.subjectlichexanthone
dc.subjectmethyl protocetrate
dc.subjectnitric oxide
dc.subjectnitroblue tetrazolium
dc.subjectnorstitic acid
dc.subjectphenol derivative
dc.subjectphysodic acid
dc.subjectprotocetraric acid
dc.subjectunclassified drug
dc.subjectanimal cell
dc.subjectcell stimulation
dc.subjectcell viability
dc.subjectcytotoxicity
dc.subjectdrug determination
dc.subjectdrug structure
dc.subjectdrug synthesis
dc.subjectimmune response
dc.subjectimmunomodulation
dc.subjectlichen
dc.subjectmacrophage
dc.subjectmouse
dc.subjectnonhuman
dc.subjectperitoneum
dc.subjectstructure activity relation
dc.subjectsupernatant
dc.subjectSwiss Webster mouse
dc.titleImmunostimulatory effects of the phenolic compounds from lichens on nitric oxide and hydrogen peroxide productionen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rbfar/iaboutj.htm
unesp.author.lattes3538253640602977
unesp.author.orcid0000-0003-3032-2556[10]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Análises Clínicas - FCFAR
Artigos - Química Orgânica - IQ