Genetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus)

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dc.contributor.authorMarra, Nelson Mendes [UNESP]
dc.contributor.authorAmarante, Alessandro Francisco Talamini do [UNESP]
dc.contributor.authorAmarante, Mônica R.V. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:52:56Z
dc.date.available2014-05-20T13:52:56Z
dc.date.issued2007-01-01
dc.description.abstractWe investigated the resistance to Strongyloides venezuelensis primary infection of mice strains NIH (resistant) and C57BL/6 (susceptible) and the F1 and F2 offspring of crosses between these strains. The mice were infected with 2000 larvae and seven days later were sacrificed for parasite recovery and counting. There was no statistically significant (p > 0.05) sex effect on resistance. The F1 mice showed an intermediate mean number of parasites as compared to the parental NIH and C57BL6 strains. Out of 400 F2 mice, the 10% most resistant mice were infected with 21 to 97 parasites, while the 10% most susceptible mice were infected with 1027 to 1433 parasites. We also found that F2 mice with black fur (n = 72), the same color as the C57BL/6 susceptible parental strain, were more susceptible than white (n = 104) or gray furred (n = 224) mice. It is conceivable that some genes determining coat color are located on the same chromosome as where genes controlling helminth resistance.en
dc.description.affiliationUniversidade Estadual Paulista Instituto de Biociências Departamento de Parasitologia
dc.description.affiliationUnespUniversidade Estadual Paulista Instituto de Biociências Departamento de Parasitologia
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent60-64
dc.identifierhttp://dx.doi.org/10.1590/S1415-47572007000100012
dc.identifier.citationGenetics and Molecular Biology. Sociedade Brasileira de Genética, v. 30, n. 1, p. 60-64, 2007.
dc.identifier.doi10.1590/S1415-47572007000100012
dc.identifier.fileS1415-47572007000100012.pdf
dc.identifier.issn1415-4757
dc.identifier.lattes2677231663329706
dc.identifier.lattes5079380279933540
dc.identifier.orcid0000-0002-5929-1223
dc.identifier.scieloS1415-47572007000100012
dc.identifier.urihttp://hdl.handle.net/11449/18888
dc.language.isoeng
dc.publisherSociedade Brasileira de Genética
dc.relation.ispartofGenetics and Molecular Biology
dc.relation.ispartofjcr1.493
dc.relation.ispartofsjr0,638
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectmiceen
dc.subjectStrongyloides venezuelensisen
dc.subjectresistanceen
dc.subjectgeneticsen
dc.titleGenetic basis of the resistance to Strongyloides venezuelensis (Nematoda, Rhabdiasidae) infection in mice (Mus musculus)en
dc.typeArtigo
unesp.author.lattes2677231663329706[2]
unesp.author.lattes5079380279933540
unesp.author.orcid0000-0002-5929-1223[3]
unesp.author.orcid0000-0003-3995-5501[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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Artigos - Parasitologia - IBB