Remodeling of cortical and corticocancellous fresh-frozen allogeneic block bone grafts - a radiographic and histomorphometric comparison to autologous bone grafts

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dc.contributor.authorSpin Neto, Rubens
dc.contributor.authorStavropoulos, Andreas
dc.contributor.authorColetti, Felipe L. [UNESP]
dc.contributor.authorPereira, Luís A. V. D.
dc.contributor.authorMarcantonio Júnior, Elcio [UNESP]
dc.contributor.authorWenzel, Ann
dc.contributor.institutionAarhus University
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2015-08-06T16:12:40Z
dc.date.available2015-08-06T16:12:40Z
dc.date.issued2014
dc.description.abstractObjectives: To compare cortical (AL-C) and corticocancellous (AL-CC) fresh-frozen block bone allografts to cortical block bone autografts (AT) used for lateral ridge augmentation in terms of radiographic dimensional maintenance and histomorphometrical graft remodeling. Materials and methods: Twenty-four patients, requiring ridge augmentation in the anterior maxilla prior to implant placement, were treated with AT, AL-C or AL-CC bone blocks (eight patients per graft type). Patients were examined with CBCT prior to, 14 days, and 6–8 months after grafting. Amount of augmentation and dimensional block graft maintenance over time was evaluated by comparing planimetric measurements of the alveolar ridge made on CBCT sections of the augmentation area. During implant installation surgery, 6–8 months after grafting, cylindrical biopsies were harvested perpendicularly to the lateral aspect of the augmented alveolar ridge. The relative volumes of vital and necrotic bone and soft tissues were histomorphometrically estimated. Comparisons among groups and observation times were performed using Friedman test followed by Dunn’s post-hoc test. Results: Radiographic evaluation showed that the three types of grafts resulted in a significant increase in alveolar ridge width, with no significant differences among the groups in terms of ridge dimensions at the various observation times. However, significant graft resorption (P = 0.03) was observed in the AL-CC group over time (8.3 7.1%) compared with the AT and AL-C groups, where a slight increase was observed, on average (1.5 20.6% and 1.3 14.9%, respectively). Histomorphometrical analysis showed that larger amounts of vital bone were found in the biopsies from the AT augmented sites (25.1 11.2%) compared with AL-CC and AL-C augmented sites (9.3 3.8% and 3.9 4.6%, respectively; P ≤ 0.01). AL-CC and AT biopsies had the smallest amount of necrotic bone (38.2 12.1% and 56.7 26.0, respectively) compared with AL-C (83.7 10.8%, P < 0.01) biopsies. AL-CC biopsies showed the largest amount of soft tissues (52.5 11.7%) compared with those from AT (18.1 17.1%, P = 0.03) and AL-C (12.3 8.5%, P < 0.01) sites. Conclusions: AL block bone graft architecture influences significantly its dimensional incorporation and remodeling. Compared with AT bone graft, a small portion of the AL block consists of vital bone 6–8 months after grafting. Cortical AL blocks seem to show the least amounts of vital bone, while corticocancellous AL blocks seem to undergo more resorption over time. Among theen
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, RUA HUMAITÁ Nº 1680, CENTRO, CEP 14801903, SP, Brasil
dc.description.affiliationDepartment of Dentistry - Periodontology, Aarhus University, Aarhus, Denmark
dc.description.affiliationDepartment of Histology and Embryology, UNICAMP – State University ofCampinas, Institute of Biology, Campinas, S~ao Paulo, Brazil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara, Araraquara, RUA HUMAITÁ Nº 1680, CENTRO, CEP 14801903, SP, Brasil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2008/09207-9
dc.description.sponsorshipIdCAPES: 0050/10-5
dc.format.extent747–752
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/clr.12343/full#references
dc.identifier.citationClinical Oral Implants Research, v. 26, n. 7, p. 747-752, 2014.
dc.identifier.doi10.1111/clr.12343
dc.identifier.issn0905-7161
dc.identifier.lattes4943293233044062
dc.identifier.lattes6100859465871929
dc.identifier.urihttp://hdl.handle.net/11449/125631
dc.language.isoeng
dc.relation.ispartofClinical Oral Implants Research
dc.relation.ispartofjcr4.305
dc.relation.ispartofsjr2,462
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectAutogenous boneen
dc.subjectBone augmentationen
dc.subjectFresh-frozen allogeneic boneen
dc.subjectHistologyen
dc.subjectHumanen
dc.subjectOsseointegrationen
dc.titleRemodeling of cortical and corticocancellous fresh-frozen allogeneic block bone grafts - a radiographic and histomorphometric comparison to autologous bone graftsen
dc.typeArtigo
unesp.author.lattes4943293233044062
unesp.author.lattes6100859465871929
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
unesp.departmentDiagnóstico e Cirurgiapt

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