Involvement of serotoninergic receptors in the anteroventral preoptic region on hypoxia-induced hypothermia

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dc.contributor.authorGargaglioni, L. H.
dc.contributor.authorSteiner, A. A.
dc.contributor.authorBranco, LGS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSt Josephs Hosp
dc.contributor.institutionMed Ctr
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:15:30Z
dc.date.available2014-05-20T13:15:30Z
dc.date.issued2005-05-17
dc.description.abstractHypoxia causes a regulated decrease in body temperature (Tb). There is circumstantial evidence that the neurotransmitter serotonin (5-HT) in the anteroventral preoptic region (AVPO) mediates this response. However, which 5-HT receptor(s) is (are) involved in this response has not been assessed. Thus, we investigated the participation of the 5-HT receptors (5-HT(1), 5-HT(2), and 5-HT(7)) in the AVPO in hypoxic hypothermia. To this end, Tb of conscious Wistar rats was monitored by biotelemetry before and after intra-AVPO microinjection of methysergide (a 5-HT(1) and 5-HT(2) receptor antagonist, 0.2 and 2 mu g/100 nL), WAY-100635 (a 5-HT(1A) receptor antagonist, 0.3 and 3 mu g/100 nL), and SB-269970 (a 5-HT(7) receptor antagonist, 0.4 and 4 mu/100 nL), followed by 60 min of hypoxia exposure (7% O(2)). During the experiments, the mean chamber temperature was 24.6 +/- 0.7 degrees C (mean +/- SE) and the mean room temperature was 23.5 +/- 0.8 degrees C (mean +/- SE). Intra-AVPO microinjection of vehicle or 5-HT antagonists did not change Tb during normoxic conditions. Exposure of rats to 7% of inspired oxygen evoked typical hypoxia-induced hypothermia after vehicle microinjection, which was not affected by both doses of methysergide. However, WAY-100635 and SB-269970 treatment attenuated the drop in Tb in response to hypoxia. The effect was more pronounced with the 5-HT7 antagonist since both doses (0.4 and 4 mu g/0.1 mu L) were capable of attenuating the hypothermic response. As to the 5-HT(1A) antagonist, the attenuation of hypoxia-induced hypothermia was only observed at the higher dose. Therefore, the present results are consistent with the notion that 5-HT acts on both 5-HT(1A) and 5-HT7 receptors in the AVPO to induce hypothermia, during hypoxia. (c) 2005 Elsevier B.V All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciências, Dept Morfol & Fisiol Anim, Jaboticabal, SP, Brazil
dc.description.affiliationSt Josephs Hosp, System Inflammat Lab, Phoenix, AZ 85013 USA
dc.description.affiliationMed Ctr, Phoenix, AZ 85013 USA
dc.description.affiliationUniv São Paulo, Dent Sch Ribeirao Preto, Dept Morphol Stomatol & Physiol, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências, Dept Morfol & Fisiol Anim, Jaboticabal, SP, Brazil
dc.format.extent16-24
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2005.02.069
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1044, n. 1, p. 16-24, 2005.
dc.identifier.doi10.1016/j.brainres.2005.02.069
dc.identifier.issn0006-8993
dc.identifier.urihttp://hdl.handle.net/11449/2631
dc.identifier.wosWOS:000229276700003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectserotoninpt
dc.subjectHypoxiapt
dc.subjecthypothermiapt
dc.subjectpreoptic areapt
dc.subjectthen noregulationpt
dc.titleInvolvement of serotoninergic receptors in the anteroventral preoptic region on hypoxia-induced hypothermiaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-0802-4619[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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Artigos - Morfologia e Fisiologia Animal - FCAV