Potentiometric determination of alendronate in pharmaceutical formulations

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dc.contributor.authorDe Haro Moreno, Andréia [UNESP]
dc.contributor.authorPezza, Helena Redigolo [UNESP]
dc.contributor.authorPezza, Leonardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:47:20Z
dc.date.available2022-04-29T08:47:20Z
dc.date.issued2004-12-01
dc.description.abstractA simple, precise, fast and low-cost potentiometric method for alendronate determination in pharmaceutical formulations has been proposed. Alendronate present in tablets at the known concentration was potentiometrically titrated in an aqueous solution using a combined glass electrode coupled with an autotitrator. Determination limit of alendronate was 20.0 μg mL-1. In the presence of common excipients, such as lactose, microcrystalline cellulose, glucose, croscarmellose sodium, starch, talc, magnesium stearate and titanium dioxide no interferences were observed. The method proposed was validated by determining alendronate in various dosage forms. The average RSD was 0.75%.en
dc.description.affiliationInstituto de Química UNESP, P.O.Box 355, CEP 14801-970, Araraquara, SP
dc.description.affiliationUnespInstituto de Química UNESP, P.O.Box 355, CEP 14801-970, Araraquara, SP
dc.format.extent351-357
dc.identifier.citationChemia Analityczna, v. 49, n. 3, p. 351-357, 2004.
dc.identifier.issn0009-2223
dc.identifier.scopus2-s2.0-19544366456
dc.identifier.urihttp://hdl.handle.net/11449/231758
dc.language.isoeng
dc.relation.ispartofChemia Analityczna
dc.sourceScopus
dc.subjectAlendronate
dc.subjectPharmaceutical formulations
dc.subjectPotentiometric determination
dc.titlePotentiometric determination of alendronate in pharmaceutical formulationsen
dc.typeArtigo

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