Latin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical course

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dc.contributor.authorLombardi, Raúl
dc.contributor.authorFerreiro, Alejandro
dc.contributor.authorPonce, Daniela [UNESP]
dc.contributor.authorClaure-Del Granado, Rolando
dc.contributor.authorAroca, Gustavo
dc.contributor.authorVenegas, Yanissa
dc.contributor.authorPereira, Mariana
dc.contributor.authorChavez-Iñiguez, Jonathan
dc.contributor.authorRojas, Nelson
dc.contributor.authorVilla, Ana
dc.contributor.authorColombo, Marcos
dc.contributor.authorCarlino, Cristina
dc.contributor.authorGuimarâes, Caio
dc.contributor.authorYounes-Ibrahim, Mauricio
dc.contributor.authorRizo, Lilia Maria
dc.contributor.authorGuzmán, Gisselle
dc.contributor.authorVarela, Carlos
dc.contributor.authorRosa-Diez, Guillermo
dc.contributor.authorJaniques, Diego
dc.contributor.authorAyala, Roger
dc.contributor.authorCoronel, Galo
dc.contributor.authorRoessler, Eric
dc.contributor.authorAmor, Serena
dc.contributor.authorOsorio, Washington
dc.contributor.authorRivas, Natalia
dc.contributor.authorPereira, Benedito
dc.contributor.authorde Azevedo, Caroline
dc.contributor.authorFlores, Adriana
dc.contributor.authorUbillo, José
dc.contributor.authorRaño, Julieta
dc.contributor.authorYu, Luis
dc.contributor.authorBurdmann, Emmanuel A.
dc.contributor.authorRodríguez, Luis
dc.contributor.authorGalagarza-Gutiérrez, Gianny
dc.contributor.authorCuritomay-Cruz, Jesús
dc.contributor.institutionUniversidad de la República
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidad Mayor de San Simón
dc.contributor.institutionUniversidad Simón Bolívar
dc.contributor.institutionServicio de Nefrología
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionHospital Civil de Guadalajara
dc.contributor.institutionHospital General de Agudos Dr Cosme Argerich
dc.contributor.institutionServiço de Nefrología
dc.contributor.institutionHospital Provincial
dc.contributor.institutionPontificia Universidade Catolica do Rio de Janeiro
dc.contributor.institutionUniversity of Rio de Janeiro
dc.contributor.institutionNephrology Hospital Universitario Dr JoséEleuterio González
dc.contributor.institutionCentros de Diagnóstico y Medicina Avanzada
dc.contributor.institutionHospital Italiano
dc.contributor.institutionSalud Renal MSP
dc.contributor.institutionPontificia Universidad Católica de Chile
dc.contributor.institutionHospital Español
dc.contributor.institutionHospital de Especialidades de las Fuerzas Armadas
dc.contributor.institutionHospital Rojas
dc.contributor.institutionUniversidade de Sá
dc.contributor.institutionHospital Regional General Dr Carlos Mac Gregor Sanchez Navarro
dc.contributor.institutionHospital de Pediatría CMN Siglo XXI
dc.contributor.institutionCentro Infantil del Riñón
dc.contributor.institutionHospital Regional de Ica
dc.contributor.institutionHospital Nacional Hipólito Unanue
dc.date.accessioned2022-04-28T19:50:12Z
dc.date.available2022-04-28T19:50:12Z
dc.date.issued2022-01-01
dc.description.abstractThe Latin American Society of Nephrology and Hypertension conducted a prospective cohort, multinational registry of Latin American patients with kidney impairment associated to COVID-19 infection with the objective to describe the characteristics of acute kidney disease under these circumstances. The study was carried out through open invitation in order to describe the characteristics of the disease in the region. Eight-hundred and seventy patients from 12 countries were included. Median age was 63 years (54-74), most of patients were male (68.4%) and with diverse comorbidities (87.2%). Acute kidney injury (AKI) was hospital-acquired in 64.7% and non-oliguric in 59.9%. Multiorgan dysfunction syndrome (MODS) due to COVID-19 and volume depletion were the main factors contributing to AKI (59.2% and 35.7% respectively). Kidney replacement therapy was started in 46.2%. Non-recovery of renal function was observed in 65.3%. 71.5% of patients were admitted to ICU and 72.2% underwent mechanical ventilation. Proteinuria at admission was present in 62.4% of patients and proteinuria during hospital-stay occurred in 37.5%. Those patients with proteinuria at admission had higher burden of comorbidities, higher baseline sCr, and MODS was severe. On the other hand, patients with de novo proteinuria had lower incidence of comorbidities and near normal sCr at admission, but showed adverse course of disease. COVID-19 MODS was the main cause of AKI in both groups. All-cause mortality of the general population was 57.4%, and it was associated to age, sepsis as cause of AKI, severity of condition at admission, oliguria, mechanical ventilation, non-recovery of renal function, in-hospital complications and hospital stay. In conclusion, our study contributes to a better knowledge of this condition and highlights the relevance of the detection of proteinuria throughout the clinical course.en
dc.description.affiliationDepartment of Nephrology Universidad de la República
dc.description.affiliationClinical Hospital of Botucatu School Medicine HCFMB University of Sao Paulo State UNESP
dc.description.affiliationHospital Obrero #2-C. N.S. School of Medicine Universidad Mayor de San Simón
dc.description.affiliationUniversidad Simón Bolívar
dc.description.affiliationHospital Nacional Arzobispo Loayza Servicio de Nefrología
dc.description.affiliationSchool of Medicine University of São Paulo
dc.description.affiliationDivision of Nephrology Hospital Civil de Guadalajara
dc.description.affiliationDepartamento de Nefrología Hospital General de Agudos Dr Cosme Argerich
dc.description.affiliationServiço de Nefrología, Jau Santa Casa de Jau
dc.description.affiliationDepartment of Nephrology Hospital Provincial
dc.description.affiliationNefrologia Pontificia Universidade Catolica do Rio de Janeiro
dc.description.affiliationInternal Medicine University of Rio de Janeiro
dc.description.affiliationNephrology Hospital Universitario Dr JoséEleuterio González
dc.description.affiliationCentros de Diagnóstico y Medicina Avanzada
dc.description.affiliationServicio de Nefrología Hospital Italiano
dc.description.affiliationDepartamento de Medicina Interna Salud Renal MSP
dc.description.affiliationDepartment of Nephrology Pontificia Universidad Católica de Chile
dc.description.affiliationServicio de Nefrología Hospital Español
dc.description.affiliationDepartamento de Nefrología Hospital de Especialidades de las Fuerzas Armadas
dc.description.affiliationServicio de Nefrología y Diálisis Hospital Rojas
dc.description.affiliationNephrology School of Medicine University of São Paulo
dc.description.affiliationHospital Federal Cardozo Fontes Universidade de Sá
dc.description.affiliationDepartamento de Nefrología Hospital Regional General Dr Carlos Mac Gregor Sanchez Navarro
dc.description.affiliationDepartamento de Nefrología Hospital de Pediatría CMN Siglo XXI
dc.description.affiliationDepartment of Nephrology School of Medicine University of Sao Paulo
dc.description.affiliationCentro Infantil del Riñón, Tucumán
dc.description.affiliationHospital Regional de Ica
dc.description.affiliationHospital Nacional Hipólito Unanue
dc.description.affiliationUnespClinical Hospital of Botucatu School Medicine HCFMB University of Sao Paulo State UNESP
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0261764
dc.identifier.citationPLoS ONE, v. 17, n. 1 January, 2022.
dc.identifier.doi10.1371/journal.pone.0261764
dc.identifier.issn1932-6203
dc.identifier.scopus2-s2.0-85123730940
dc.identifier.urihttp://hdl.handle.net/11449/223363
dc.language.isoeng
dc.relation.ispartofPLoS ONE
dc.sourceScopus
dc.titleLatin American registry of renal involvement in COVID-19 disease. The relevance of assessing proteinuria throughout the clinical courseen
dc.typeArtigo

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