Griseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activities

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dc.contributor.authorChapla, Vanessa M. [UNESP]
dc.contributor.authorZeraik, Maria L. [UNESP]
dc.contributor.authorCafeu, Mariana C. [UNESP]
dc.contributor.authorSilva, Geraldo H.
dc.contributor.authorCavalheiro, Alberto J. [UNESP]
dc.contributor.authorBolzani, Vanderlan S. [UNESP]
dc.contributor.authorYoung, Maria C.M.
dc.contributor.authorPfenning, Ludwig H.
dc.contributor.authorAraujo, Angela R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal Do Tocantins (UFT)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.contributor.institutionInstituto de Botânica
dc.contributor.institutionUniversidade Federal de Lavras (UFLA)
dc.date.accessioned2018-12-11T17:37:32Z
dc.date.available2018-12-11T17:37:32Z
dc.date.issued2018-08-01
dc.description.abstractOne new natural product, 1-phenylethyl-O-α-L-rhamnopyranoside, together with eight known diketopiperazines and two benzene derivatives were isolated from the endophytic fungus Colletotrichum crassipes, whereas six known compounds including two griseofulvins, three cytochalasins and one dihydroisocoumarin were produced from the endophyte Xylaria sp., both endophytic fungi are associated with leaves of Casearia sylvestris. Cyclo(D)-Pro-(D)-Phe, N-(2-phenylethyl)acetamide and 5-carboxy-6-hydroxy-3-methyl-3,4-dihydroisocoumarin exhibited potent antifungal activity against Cladosporium cladosporioides and C. sphaerospermum. The compounds cyclo(D)-Pro-(D)-Phe, griseofulvin, cytochalasin B and cytochalasin D exhibited antioxidant activity, and the compounds cyclo(D)-Pro-(D)-Phe, cytochalasin B and cytochalasin C showed potent acetylcholinesterase (AChE) inhibition. In addition, this is the first report on the isolation of secondary metabolites from two endophytic fungal strains, associated with Casearia sylvestris. Printed in Brazil-en
dc.description.affiliationNúcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Instituto de Química Universidade Estadual Paulista (Unesp)
dc.description.affiliationCurso de Química Ambiental Universidade Federal Do Tocantins (UFT)
dc.description.affiliationLaboratório de Fitoquímica e Biomoléculas (LabFitoBio) Departamento de Química Universidade Estadual de Londrina (UEL)
dc.description.affiliationInstituto de Ciências Exatas e Tecnológicas Universidade Federal de Viçosa
dc.description.affiliationSeção de Fisiologia e Bioquímica de Plantas Instituto de Botânica
dc.description.affiliationDepartamento de Fitopatologia Universidade Federal de Lavras
dc.description.affiliationUnespNúcleo de Bioensaios Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE) Instituto de Química Universidade Estadual Paulista (Unesp)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2011/03017-6
dc.format.extent1707-1713
dc.identifierhttp://dx.doi.org/10.21577/0103-5053.20180045
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 29, n. 8, p. 1707-1713, 2018.
dc.identifier.doi10.21577/0103-5053.20180045
dc.identifier.fileS0103-50532018000801707.pdf
dc.identifier.issn1678-4790
dc.identifier.issn0103-5053
dc.identifier.scieloS0103-50532018000801707
dc.identifier.scopus2-s2.0-85049055444
dc.identifier.urihttp://hdl.handle.net/11449/179981
dc.language.isoeng
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.ispartofsjr0,357
dc.relation.ispartofsjr0,357
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBiological activity
dc.subjectCasearia sylvestris
dc.subjectColletotrichum crassipes
dc.subjectEndophytic fungi
dc.subjectXylaria sp.
dc.titleGriseofulvin, diketopiperazines and cytochalasins from endophytic fungi colletotrichum crassipes and Xylaria sp., and their antifungal, antioxidant and anticholinesterase activitiesen
dc.typeArtigo
unesp.author.lattes2518006820764120[5]
unesp.author.lattes0037579054083160[9]
unesp.author.orcid0000-0001-8214-9957[5]
unesp.author.orcid0000-0001-7616-9652[9]

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