Inhibitory effect of deferoxamine on Paracoccidioides brasiliensis survival in human monocytes: Reversal by holotransferrin not by apotransferrin

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dc.contributor.authorDias-Melicio, Luciane Alarcão [UNESP]
dc.contributor.authorCalvi, Sueli Aparecida [UNESP]
dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.authorSoares, Ângela Maria Victoriano de Campos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:36Z
dc.date.available2014-05-27T11:21:36Z
dc.date.issued2005-09-01
dc.description.abstractThe mechanisms used by Paracoccidioides brasiliensis to survive into phagocytic cells are not clear. Cellular iron metabolism is of critical importance to the growth of several intracellular pathogens whose capacity to multiply in mononuclear phagocytes is dependent on the availability of intracellular iron. Thus, the objective of this paper was to investigate the role of intracellular iron in regulating the capacity of P. brasiliensis yeast cells to survive within human monocytes. Treatment of monocytes with deferoxamine, an iron chelator, suppressed the survival of yeasts in a concentration-dependent manner. The effect of deferoxamine was reversed by iron-saturated transferrin (holotransferrin) but not by nonsaturated transferrin (apotransferrin). These results strongly suggest that P. brasiliensis survival in human monocytes is iron dependent.en
dc.description.affiliationDepartment of Microbiology and Immunology Biosciences Institute São Paulo State University, Botucatu, SP
dc.description.affiliationDepartment of Tropical Diseases Medical School São Paulo State University, Botucatu, SP
dc.description.affiliationDepartment of Microbiology and Immunology Biosciences Institute UNESP, 18618-000 Botucatu, S. Paulo
dc.description.affiliationUnespDepartment of Microbiology and Immunology Biosciences Institute São Paulo State University, Botucatu, SP
dc.description.affiliationUnespDepartment of Tropical Diseases Medical School São Paulo State University, Botucatu, SP
dc.description.affiliationUnespDepartment of Microbiology and Immunology Biosciences Institute UNESP, 18618-000 Botucatu, S. Paulo
dc.format.extent263-266
dc.identifierhttp://dx.doi.org/10.1590/S0036-46652005000500005
dc.identifier.citationRevista do Instituto de Medicina Tropical de Sao Paulo, v. 47, n. 5, p. 263-266, 2005.
dc.identifier.doi10.1590/S0036-46652005000500005
dc.identifier.file2-s2.0-27644560633.pdf
dc.identifier.issn0036-4665
dc.identifier.issn1678-9946
dc.identifier.lattes2179450022699059
dc.identifier.lattes6486557387397806
dc.identifier.scieloS0036-46652005000500005
dc.identifier.scopus2-s2.0-27644560633
dc.identifier.urihttp://hdl.handle.net/11449/68385
dc.language.isoeng
dc.relation.ispartofRevista do Instituto de Medicina Tropical de São Paulo
dc.relation.ispartofjcr1.489
dc.relation.ispartofsjr0,669
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDeferoxamine
dc.subjectIron
dc.subjectMonocytes
dc.subjectParacoccidioides brasiliensis
dc.subjectapotransferrin
dc.subjectdeferoxamine
dc.subjectholotransferrin
dc.subjectiron chelate
dc.subjectunclassified drug
dc.subjectcell culture
dc.subjectcell level
dc.subjectcontrolled study
dc.subjectculture medium
dc.subjectfungus growth
dc.subjecthuman
dc.subjecthuman cell
dc.subjectiron metabolism
dc.subjectmonocyte
dc.subjectnonhuman
dc.subjectphagocyte
dc.subjectsurvival
dc.subjectApoproteins
dc.subjectHumans
dc.subjectParacoccidioides
dc.subjectSiderophores
dc.subjectTransferrin
dc.titleInhibitory effect of deferoxamine on Paracoccidioides brasiliensis survival in human monocytes: Reversal by holotransferrin not by apotransferrinen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/rimtsp/paboutj.htm
unesp.author.lattes2179450022699059
unesp.author.lattes6486557387397806
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Microbiologia e Imunologia - IBB
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