Estresse oxidativo nos estágios finais da doença renal crônica em pequenos animais

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dc.contributor.authorGalvão, A. L B [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:24:32Z
dc.date.available2014-05-27T11:24:32Z
dc.date.issued2009-12-01
dc.description.abstractThe chronic kidney disease (CKD) it is characterized by irreversible structural lesions that can develop progressively for uremia and chronic renal failure (CRF). In the CRF it happens the incapacity of executing the functions of maintenance of the electrolyte balance and acid-base, catabolitos excretion and hormonal regulation appropriately. When the mechanism basic physiopathology of the renal upset is analyzed, it is observed that present factors, predispose to the unbalance oxidative. Most of the time, the renal patient comes badly nurtured, with lack in reservations of vitamins and minerals, what reduces the antioxidant defense mechanisms, what favors the installation of the renal oxidative stress, with the formation of species you reactivate of reactive oxygen species (ROS), substances these potentially harmful to the organism. The reduction of the glomerular filtration rate (GFR) in the evolution of CKD in dogs and cats is a component for the installation of the renal oxidative stress. The ROS possesses important action in the kidneys, and these substances are highly reactivate, and when presents in excess damage lipids, proteins, DNA and carbohydrate, driving functional and structural abnormalities taking the cellular apoptosis and necrosis. Against the harmful potential action of these substances you reactivate, she becomes fundamental a delicate control of his production and consumption in the half intracellular, in other words, a balance of his concentration intra and extracellular. That is possible due to the activity of the antioxidants. Like this, to present literature revision had as objective describes the participation of the oxidative stress in CRF, as well as the mechanisms defenses against the harmful action of those substances.en
dc.description.affiliationMedicina Veterinária Faculdade de Ciências Agrárias e Veterinárias (FCAV/UNESP), Jaboticabal, SP
dc.description.affiliationUnespMedicina Veterinária Faculdade de Ciências Agrárias e Veterinárias (FCAV/UNESP), Jaboticabal, SP
dc.format.extent178-186
dc.identifierhttp://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/article/view/16017
dc.identifier.citationArchives of Veterinary Science, v. 14, n. 3, p. 178-186, 2009.
dc.identifier.file2-s2.0-77955160297.pdf
dc.identifier.issn1517-784X
dc.identifier.scopus2-s2.0-77955160297
dc.identifier.urihttp://hdl.handle.net/11449/71405
dc.language.isopor
dc.relation.ispartofArchives of Veterinary Science
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntioxidants
dc.subjectCats
dc.subjectDogs
dc.subjectKidney disease
dc.subjectAnimalia
dc.subjectCanis familiaris
dc.titleEstresse oxidativo nos estágios finais da doença renal crônica em pequenos animaispt
dc.title.alternativeOxidative stress in end-stage chronic kidney disease in small animalsen
dc.typeArtigo
dcterms.licensehttp://ojs.c3sl.ufpr.br/ojs2/index.php/veterinary/about/editorialPolicies#openAccessPolicy

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