The realm of cellulases in biorefinery development

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dc.contributor.authorChandel, Anuj K.
dc.contributor.authorChandrasekhar, G.
dc.contributor.authorSilva, Messias Borges
dc.contributor.authorSilvério Da Silva, Silvio
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionJawaharlal Nehru Technological University
dc.contributor.institutionFaculty of Engineering of Guaratingueta
dc.date.accessioned2022-04-29T08:44:30Z
dc.date.available2022-04-29T08:44:30Z
dc.date.issued2012-09-01
dc.description.abstractGeopolitical concerns (unstable supply of gasoline, environmental pollution, and regular price hikes), economic, and employment concerns have been prompting researchers, entrepreneurs, and policy makers to focus on harnessing the potential of lignocellulosic feedstock for fuel ethanol production and its commercialization. The carbohydrate skeleton of plant cell walls needs to be depolymerised into simpler sugars for their application in fermentation reactions as a chief carbon source of suitable ethnologic strains for ethanol production. The role of cellulolytic enzymes in the degradation of structural carbodydrates of the plant cell wall into ready-to-fermentable sugar stream is inevitable. Cellulase synergistically acts upon plant cell wall polysaccharides to release glucose into the liquid media. Cellulase predominantly dominates all the plant cell wall degrading enzymes due to their vast and diverse range of applications. Apart from the major applications of cellulases such as in detergent formulations, textile desizing, and development of monogastric feed for ruminants, their role in biorefinery is truly remarkable. This is a major area where new research tools based upon fermentation based formulations, biochemistry, and system biology to expedite the structurefunction relationships of cellulases including cellulosomes and new designer enzymatic cocktails are required. In the last two decades, a considerable amount of research work has been performed on cellulases and their application in biomass saccharification. However, there are still technical and economic impediments to the development of an inexpensive commercial cellulase production process. Advancements in biotechnology such as screening of microorganisms, manipulation of novel cellulase encoding traits, site-specific mutagenesis, and modifications to the fermentation process could enhance the production of cellulases. Commercially, cheaper sources of carbohydrates and modified fermentation conditions could lead to more cost-effective production of cellulases with the goal to reduce the cost of ethanol production from lignocellulosics. Implementation of integrated steps like cellulase production and cellulase mediated saccharification of biomass in conjunction with the fermentation of released sugars in ethanol in a single step so called consolidated bio-processing (CBP) is very important to reduce the cost of bioethanol. This paper aims to explore and review the important findings in cellulase biotechnology and the forward path for new cutting edge opportunities in the success of biorefineries. © 2012 Informa Healthcare USA, Inc.en
dc.description.affiliationDepartment of Biotechnology School of Engineering of Lorena University of São Paulo, Estrada Municipal do Campinho, Caixa Postal 116, 12.602.810 Lorena/SP
dc.description.affiliationCentre for Biotechnology Jawaharlal Nehru Technological University, Hyderabad-500 072
dc.description.affiliationFaculty of Engineering of Guaratingueta Department of Production, CEP12.5160410- Guaratingueta, São Paulo
dc.format.extent187-202
dc.identifierhttp://dx.doi.org/10.3109/07388551.2011.595385
dc.identifier.citationCritical Reviews in Biotechnology, v. 32, n. 3, p. 187-202, 2012.
dc.identifier.doi10.3109/07388551.2011.595385
dc.identifier.issn0738-8551
dc.identifier.issn1549-7801
dc.identifier.scopus2-s2.0-84864684456
dc.identifier.urihttp://hdl.handle.net/11449/231288
dc.language.isoeng
dc.relation.ispartofCritical Reviews in Biotechnology
dc.sourceScopus
dc.subjectBiorefinery
dc.subjectCellulases
dc.subjectCellulose saccharification
dc.subjectFermentation
dc.subjectLignocellulose
dc.titleThe realm of cellulases in biorefinery developmenten
dc.typeResenha

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