Preparation, characterization and evaluation of drug-delivery systems: Pectin and mefenamic acid films

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dc.contributor.authorMoreira, R. B.
dc.contributor.authorTeixeira, J. A.
dc.contributor.authorFuruyama-Lima, Aline Margarete [UNESP]
dc.contributor.authorSouza, N. C. de
dc.contributor.authorSiqueira, A. B.
dc.contributor.institutionUniv Fed Mato Grosso
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:54:05Z
dc.date.available2015-03-18T15:54:05Z
dc.date.issued2014-08-20
dc.description.abstractMefenamic acid (H-Mef) is a nonsteroidal anti-inflammatory drug (NSAID). Various adhesive dosage forms of NSAIDs have been developed, which include adhesive tablets, gels, ointments, patches and more recently, polymeric films. The objective of this study was the development of H-Mef adhesive films to be used as a drug-delivery system with different ratios of pectin and calcium chloride dihydrate by the casting technique. The materials were characterized by TG-DSC coupled FTIR, AFM (atomic force microscopy) and spectroscopic techniques. The results provided information about the dehydration, film roughness, surface morphology, thermal decomposition, as well as identification of gaseous products evolved during thermal decomposition. The characterizations indicated the A5 and A6 films functioned well, with 99% H-Mef released within 15 min at pH 5, suggesting these degradable films could be used as a topical delivery system. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Mato Grosso, BR-78600000 Barra Do Garcas, MT, Brazil
dc.description.affiliationUniv Fed Mato Grosso, BR-78060900 Cuiaba, MT, Brazil
dc.description.affiliationUniv Estadual Paulista, IBILCE, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, IBILCE, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
dc.description.sponsorshipLaboratorio de Analise Termica Ivo Giolito (LATIG) IQ-UNESP-SP-Brazil
dc.description.sponsorshipFAPEMAT
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent100-106
dc.identifierhttp://dx.doi.org/10.1016/j.tca.2014.06.018
dc.identifier.citationThermochimica Acta. Amsterdam: Elsevier Science Bv, v. 590, p. 100-106, 2014.
dc.identifier.doi10.1016/j.tca.2014.06.018
dc.identifier.issn0040-6031
dc.identifier.urihttp://hdl.handle.net/11449/116759
dc.identifier.wosWOS:000340853100010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofThermochimica Acta
dc.relation.ispartofjcr2.189
dc.relation.ispartofsjr0,605
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPectinen
dc.subjectMefenamic aciden
dc.subjectFilmsen
dc.subjectThermal behaviouren
dc.titlePreparation, characterization and evaluation of drug-delivery systems: Pectin and mefenamic acid filmsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-6557-9557[2]
unesp.author.orcid0000-0001-8554-1663[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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