Profiling the Cymbopogon nardus Ethanol Extract and Its Antifungal Potential against Candida Species with Different Patterns of Resistance

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dc.contributor.authorde Toledo, Luciani G. [UNESP]
dc.contributor.authorRamos, Matheus A.S. [UNESP]
dc.contributor.authorSpósito, Larissa [UNESP]
dc.contributor.authorCastilho, Elza M. [UNESP]
dc.contributor.authorPavan, Fernando R. [UNESP]
dc.contributor.authorLopes, Érica O. [UNESP]
dc.contributor.authorda Silva, Isabel C. [UNESP]
dc.contributor.authorZocolo, Guilherme J. [UNESP]
dc.contributor.authorRibeiro, Paulo R.V.
dc.contributor.authorOda, Fernando B. [UNESP]
dc.contributor.authorPereira, Juhan A.S. [UNESP]
dc.contributor.authordos Santos, André G. [UNESP]
dc.contributor.authorBauab, Taís M. [UNESP]
dc.contributor.authorde Almeida, Margarete T.G.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.date.accessioned2021-06-25T10:35:09Z
dc.date.available2021-06-25T10:35:09Z
dc.date.issued2020-09-01
dc.description.abstractThe essential oil of Cymbopogon nardus, citronella, has been extensively studied. However, the chemical and biological properties of the ethanolic extract (EE) of C. nardus have not been evaluated. The aim of this study was to characterize the chemical composition of the EE of C. nardus and its active fraction (FrD). Moreover, the cytotoxic and antifungal properties of these extracts against Candida species with different resistance profiles to conventional drugs were evaluated. The compounds identified in EE were mono-C- and di-C-glycosyl flavones and phenylpropanoid glycosides. Phenylpropanoid glycosides were identified in FrD. EE showed antifungal activity, with minimum inhibitory concentration (MIC) values ranging from 62.5 to 500 µg mL-1. FrD was more effective against C. glabrata, as evidenced by the lowest MIC value (15.6 µg mL-1). EE inhibited yeast growth similar to amphotericin-B, as demonstrated by similar time-kill curves. EE inhibited C. albicans hyphae formation and mature biofilm of C. albicans, C. krusei and C. parapsilosis. The results of the chemical and biological analyses of EE and its fractions provided novel information and may contribute to control of infections caused by Candida species.en
dc.description.affiliationDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista (Unesp)
dc.description.affiliationDepartamento de Doenças Infecciosas Faculdade de Medicina de São José do Rio Preto (FAMERP)
dc.description.affiliationEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)
dc.description.affiliationDepartamento de Princípios Ativos Naturais e Toxicologia Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista (Unesp)
dc.description.affiliationUnespDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista (Unesp)
dc.description.affiliationUnespDepartamento de Princípios Ativos Naturais e Toxicologia Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista (Unesp)
dc.format.extent1926-1938
dc.identifierhttp://dx.doi.org/10.21577/0103-5053.20200093
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 31, n. 9, p. 1926-1938, 2020.
dc.identifier.doi10.21577/0103-5053.20200093
dc.identifier.fileS0103-50532020000901926.pdf
dc.identifier.issn1678-4790
dc.identifier.issn0103-5053
dc.identifier.scieloS0103-50532020000901926
dc.identifier.scopus2-s2.0-85092047474
dc.identifier.urihttp://hdl.handle.net/11449/206609
dc.language.isoeng
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntifungal activity
dc.subjectCandida spp
dc.subjectCymbopogon nardus
dc.subjectEthanol extract
dc.subjectFlavones
dc.subjectPhenylpropanoids
dc.titleProfiling the Cymbopogon nardus Ethanol Extract and Its Antifungal Potential against Candida Species with Different Patterns of Resistanceen
dc.typeArtigo

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Artigos - Ciências Biológicas - FCFAR
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