Evaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasms

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dc.contributor.authorCampos, Cecilia B. de[UNESP]
dc.contributor.authorDamasceno, Karine A.
dc.contributor.authorGamba, Conrado O.
dc.contributor.authorRibeiro, Ana M.
dc.contributor.authorMachado, Carla J.
dc.contributor.authorLavalle, Gleidice E.
dc.contributor.authorCassali, Geovanni D.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2015-12-07T15:39:14Z
dc.date.available2015-12-07T15:39:14Z
dc.date.issued2015-10-12
dc.description.abstractTo investigate the association of prognostic factors of feline mammary gland neoplasms, correlating them with overall survival (OS). Fifty-six primary malignant mammary gland neoplasms and 16 metastatic lymph nodes from 37 female cats were analyzed. Clinical staging, histologic type and grade, and immunohistochemistry for Ki-67, progesterone and estrogen receptor, human epidermal growth factor receptor type 2 (HER-2), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) were evaluated. Follow-up was performed in order to correlate prognostic factors with OS. Lymph node metastasis was found in 35% of cases. Clinical stage III, tubulopapillary carcinomas and histologic grade II cases prevailed in the study. Most neoplasms were positive for hormonal receptors, negative for HER-2 overexpression and presented VEGF overexpression. Immunoreactivity for Ki-67 (P = 0.046) and COX-2 (P = 0.007) was higher in metastases than in primary tumors. COX-2 (P = 0.089), HER-2 (P = 0.012) and histologic grade (P = 0.080) were correlated with OS. The data suggest that inhibition of ovarian hormones and COX-2 may represent a therapeutic option for malignant feline mammary gland neoplasms. COX-2 scores and Ki-67 index should be analyzed in primary tumors and metastases, and histologic grade, HER-2 status and COX-2 scores had a direct influence in OS. Prognostic factors allow for a better understanding of disease outcome in a condition that is characterized by a poor prognosis. The present work highlights the need for further studies on endocrine therapy and COX-2 inhibitors, which could influence OS.en
dc.description.affiliationDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences of the Sao Paulo State University (FCAV/UNESP) - Jaboticabal Campus, Jaboticabal, Brazil Laboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
dc.description.affiliationLaboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
dc.description.affiliationDepartment of Preventive and Social Medicine, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
dc.description.affiliationVeterinary Hospital, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
dc.description.affiliationLaboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil geovanni.cassali@gmail.com.
dc.description.affiliationUnespDepartment of Veterinary Clinic and Surgery, School of Agricultural and Veterinary Sciences of the Sao Paulo State University (FCAV/UNESP) - Jaboticabal Campus, Jaboticabal, Brazil Laboratory of Comparative Pathology, Department of General Pathology, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.format.extent1-10
dc.identifierhttp://dx.doi.org/10.1177/1098612X15610367
dc.identifier.citationJournal Of Feline Medicine And Surgery, p. 1-10, 2015.
dc.identifier.doi10.1177/1098612X15610367
dc.identifier.issn1532-2750
dc.identifier.pubmed26460079
dc.identifier.urihttp://hdl.handle.net/11449/131637
dc.language.isoeng
dc.publisherSAGE Publications
dc.relation.ispartofJournal Of Feline Medicine And Surgery
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.titleEvaluation of prognostic factors and survival rates in malignant feline mammary gland neoplasmsen
dc.typeArtigo
dcterms.rightsHolderSAGE Publications
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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