A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability

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dc.contributor.authorPedreiro, Liliane Neves [UNESP]
dc.contributor.authorCury, Beatriz Stringhetti Ferreira [UNESP]
dc.contributor.authorChaud, Marco Vinícius
dc.contributor.authorGremião, Maria Palmira Daflon [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de Sorocaba
dc.date.accessioned2018-12-11T17:31:34Z
dc.date.available2018-12-11T17:31:34Z
dc.date.issued2016-10-01
dc.description.abstractZidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability and bioavailability of zidovudine. SDs were prepared using the co-precipitation method followed by solvent evaporation and characterized according to their physicochemical properties such as particle size, crystallinity, thermal behavior, and liquid uptake ability. In vitro drug dissolution, mucoadhesiveness and AZT intestinal permeability were also determined. Thermal behavior and X-ray diffraction patterns demonstrated the amorphous state of AZT in SD systems. The HPMCP polymer restricted the liquid uptake ability in the acid medium; however, this property significantly increased with higher pH values. SDs allowed drug dissolution to occur in a controlled manner. HPMCP decreased the dissolution rates in the acid medium. The mucoadhesiveness of SDs was demonstrated and the permeability of AZT carried in solid dispersions was significantly improved. The effect of the SD carrier polymers on blocking efflux pump can be an important approach to improve the bioavailability of AZT.en
dc.description.affiliationFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista “Júlio de Mesquita Filho UNESP
dc.description.affiliationUniversidade de Sorocaba
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas Universidade Estadual Paulista “Júlio de Mesquita Filho UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent715-726
dc.identifierhttp://dx.doi.org/10.1590/S1984-82502016000400016
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences, v. 52, n. 4, p. 715-726, 2016.
dc.identifier.doi10.1590/S1984-82502016000400016
dc.identifier.fileS1984-82502016000400715.pdf
dc.identifier.issn2175-9790
dc.identifier.issn1984-8250
dc.identifier.lattes9129780536724256
dc.identifier.scieloS1984-82502016000400715
dc.identifier.scopus2-s2.0-85013676781
dc.identifier.urihttp://hdl.handle.net/11449/178666
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.relation.ispartofsjr0,214
dc.relation.ispartofsjr0,214
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectIntestinal permeability
dc.subjectMucoadhesion
dc.subjectP-glycoprotein
dc.subjectSolid dispersion
dc.subjectZidovudine
dc.titleA novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeabilityen
dc.typeArtigo
unesp.author.lattes9129780536724256

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Artigos - Fármacos e Medicamentos - FCFAR