Hyoscine-N-butylbromide premedication on cardiovascular variables of horses sedated with medetomidine

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dc.contributor.authorPerotta, Joao H. [UNESP]
dc.contributor.authorCanola, Paulo A. [UNESP]
dc.contributor.authorLopes, Maristela C. S. [UNESP]
dc.contributor.authorEvora, Patricia M. [UNESP]
dc.contributor.authorMartinez, Paulo E. B. [UNESP]
dc.contributor.authorEscobar, Andre [UNESP]
dc.contributor.authorValadao, Carlos A. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:45Z
dc.date.available2014-12-03T13:10:45Z
dc.date.issued2014-07-01
dc.description.abstractObjective To evaluate the effects of intravenous (IV) or intramuscular (IM) hyoscine premedication on physiologic variables following IV administration of medetomidine in horses. Study design Randomized, crossover experimental study. Animals Eight healthy crossbred horses weighing 330 +/- 39kg and aged 7 +/- 4years. Methods Baseline measurements of heart rate (HR), cardiac index (CI), respiratory rate, systemic vascular resistance (SVR), percentage of patients with second degree atrioventricular (2oAV) block, mean arterial pressure (MAP), pH, and arterial partial pressures of carbon dioxide (PaCO2) and oxygen (PaO2) were obtained 5minutes before administration of IV hyoscine (0.14mg kg-1; group HIV), IM hyoscine (0.3mg kg-1; group HIM), or an equal volume of physiologic saline IV (group C). Five minutes later, medetomidine (7.5gkg-1) was administered IV and measurements were recorded at various time points for 130minutes. Results Medetomidine induced bradycardia, 2oAV blocks and increased SVR immediately after administration, without significant changes in CI or MAP in C. Hyoscine administration induced tachycardia and hypertension, and decreased the percentage of 2oAV blocks induced by medetomidine. Peak HR and MAP were higher in HIV than HIM at 88 +/- 18beatsminute-1 and 241 +/- 37mmHg versus 65 +/- 16beatsminute-1 and 192 +/- 38mmHg, respectively. CI was increased significantly in HIV (p0.05). Respiratory rate decreased significantly in all groups during the recording period. pH, PaCO2 and PaO2 were not significantly changed by administration of medetomidine with or without hyoscine. Conclusion and clinical relevance Hyoscine administered IV or IM before medetomidine in horses resulted in tachycardia and hypertension under the conditions of this study. The significance of these changes, and responses to other dose rates, requires further investigation.en
dc.description.affiliationSao Paulo State Univ, Sch Agr Sci & Vet Med, Dept Vet Clin & Surg, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Sch Agr Sci & Vet Med, Dept Vet Clin & Surg, BR-14884900 Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 06/05274-8
dc.format.extent357-364
dc.identifierhttp://dx.doi.org/10.1111/vaa.12139
dc.identifier.citationVeterinary Anaesthesia And Analgesia. Hoboken: Wiley-blackwell, v. 41, n. 4, p. 357-364, 2014.
dc.identifier.doi10.1111/vaa.12139
dc.identifier.issn1467-2987
dc.identifier.lattes3874036760952509
dc.identifier.orcid0000-0003-4354-6487
dc.identifier.urihttp://hdl.handle.net/11449/112483
dc.identifier.wosWOS:000337599400003
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofVeterinary Anaesthesia and Analgesia
dc.relation.ispartofjcr2.064
dc.relation.ispartofsjr0,800
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBlood gas analysisen
dc.subjectEquineen
dc.subjectHyoscineen
dc.subjectMedetomidineen
dc.titleHyoscine-N-butylbromide premedication on cardiovascular variables of horses sedated with medetomidineen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
unesp.author.lattes3874036760952509[2]
unesp.author.lattes5566877625835272[7]
unesp.author.orcid0000-0003-4354-6487[2]
unesp.author.orcid0000-0001-5283-7310[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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