The Proliferating Cell Nuclear Antigen Index in Breast Aarcinomas does not Correlate with Mitotic Index and Estrogen Receptor Immunoreactivity

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dc.contributor.authorSchmitt, F. C. [UNESP]
dc.contributor.authorPereira, E. M. [UNESP]
dc.contributor.authorAndrade, L. M. [UNESP]
dc.contributor.authorTorresan, M. [UNESP]
dc.contributor.authorde Lucca, L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:54:00Z
dc.date.available2022-04-28T19:54:00Z
dc.date.issued1994-01-01
dc.description.abstractTo investigate the expression of a marker of cell proliferation (PCNA/Cyclin) and itsputative relationship with bistological grading, mitotic index and estrogen receptor immunoreactivity, we studied twenty-seven cases of invasive breast carcinoma in formalin-fixed, paraffin-embedded tissue sections. The PCNA and estrogen receptor were detected by the PC10 and H 222 monoclonal antibodies respectively, using an avidin-biotin-peroxidase method. The median value of PCNA index was 20.9% with a range from 1.4 to 84.2%. We did not find any significant relationship between PCNA index and the bistological grading, mitotic index and estrogen receptor immunoreactivity. We conclude that PCNA detected by the monoclonal antibody PC 10 in formalin-fixed material looks at present unrealiable as a proliferation marker in breast carcinoma. © 1994, Gustav Fischer Verlag · Stuttgart · Jena · New York. All rights reserved.en
dc.description.affiliationDepartments of Pathology and Gynecology and Obstetrics School ofMedicine UNESP, Botucatu, Sao Paulo
dc.description.affiliationUnespDepartments of Pathology and Gynecology and Obstetrics School ofMedicine UNESP, Botucatu, Sao Paulo
dc.format.extent786-791
dc.identifierhttp://dx.doi.org/10.1016/S0344-0338(11)80426-7
dc.identifier.citationPathology Research and Practice, v. 190, n. 8, p. 786-791, 1994.
dc.identifier.doi10.1016/S0344-0338(11)80426-7
dc.identifier.issn0344-0338
dc.identifier.scopus2-s2.0-0027931623
dc.identifier.urihttp://hdl.handle.net/11449/223972
dc.language.isoeng
dc.relation.ispartofPathology Research and Practice
dc.sourceScopus
dc.subjectBreast cancer
dc.subjectEstrogen receptor
dc.subjectPC 10
dc.subjectProliferative cell nuclear antigen
dc.titleThe Proliferating Cell Nuclear Antigen Index in Breast Aarcinomas does not Correlate with Mitotic Index and Estrogen Receptor Immunoreactivityen
dc.typeArtigo

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