Interaction of the Anti-Inflammatory Annexin A1 Protein and Tacrolimus Immunosuppressant in the Renal Function of Rats

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dc.contributor.authorAraujo, Leandro P.
dc.contributor.authorTruzzi, Renata R. [UNESP]
dc.contributor.authorMendes, Gloria E.
dc.contributor.authorLuz, Marcus A. M.
dc.contributor.authorBurdmann, Emmanuel A.
dc.contributor.authorOliani, Sonia M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionSao Jose Rio Preto Med Sch
dc.date.accessioned2014-05-20T14:00:49Z
dc.date.available2014-05-20T14:00:49Z
dc.date.issued2010-01-01
dc.description.abstractBackground: Tacrolimus (FK) is currently widely used in transplant immunosuppression and the treatment of autoimmune diseases. However, FK induces nephrotoxicity which is characterized by functional and structural renal injury. The ubiquitous protein annexin A1 (ANXA1) has potent anti-inflammatory effects and protects against ischemia/reperfusion injury. We investigated the effects of exogenous ANXA1 treatment in an experimental model of acute FK nephrotoxicity. Methods: Munich-Wistar rats received a low-salt diet for 1 week and were randomized to treatment with ANXA1 (Ac2-26 peptide 0.5 mg/kg/day s.c.), FK (6 mg/kg/day p.o.), association (FK+ANXA1) and vehicles (1 ml/kg/day) for 7 days. Results: FK induced a significant decrease in glomerular filtration rate and renal blood flow, and a significant increase in renal vascular resistance. In addition, FK caused extensive acute tubule-interstitial damage and an increase in anti-inflammatory ANXA1 expression in renal tissue. Exogenous ANXA1 treatment reduced FK-induced tubular dilatation and macrophage infiltration. For the first time, we observed that FK augmented ANXA1 expression in renal tissue. Conclusion: Exogenous ANXA1 treatment partially protected against FK-induced tubular injury and macrophage infiltration, and may be targeted in renal intervention strategies. Copyright (C) 2010 S. Karger AG, Baselen
dc.description.affiliationUNESP, IBILCE, Dept Biol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv Fed São Paulo, Postgrad Program Morphol, São Paulo, Brazil
dc.description.affiliationSao Jose Rio Preto Med Sch, Div Nephrol, Sao Jose do Rio Preto, Brazil
dc.description.affiliationUnespUNESP, IBILCE, Dept Biol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 306074/2007-9
dc.description.sponsorshipIdCNPq: 307371/2006-9
dc.description.sponsorshipIdFAPESP: 08/01048-9
dc.format.extent527-533
dc.identifierhttp://dx.doi.org/10.1159/000309756
dc.identifier.citationAmerican Journal of Nephrology. Basel: Karger, v. 31, n. 6, p. 527-533, 2010.
dc.identifier.doi10.1159/000309756
dc.identifier.issn0250-8095
dc.identifier.urihttp://hdl.handle.net/11449/21485
dc.identifier.wosWOS:000278130600007
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofAmerican Journal of Nephrology
dc.relation.ispartofjcr2.884
dc.relation.ispartofsjr1,480
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAnnexin A1en
dc.subjectTacrolimusen
dc.subjectImmunosuppressionen
dc.titleInteraction of the Anti-Inflammatory Annexin A1 Protein and Tacrolimus Immunosuppressant in the Renal Function of Ratsen
dc.typeArtigo
dcterms.rightsHolderKarger
unesp.author.orcid0000-0003-0918-2130[6]
unesp.author.orcid0000-0002-7644-8579[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Biologia - IBILCE