Spilanthol, the Principal Alkylamide from Acmella oleracea, Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice

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dc.contributor.authorDe Freitas-Blanco, Veronica Santana
dc.contributor.authorMonteiro, Karin Maia
dc.contributor.authorDe Oliveira, Patrícia Rosa [UNESP]
dc.contributor.authorDe Oliveira, Ellen Cristina Souza
dc.contributor.authorDe Oliveira Braga, Lucia Elaine
dc.contributor.authorDe Carvalho, João Ernesto
dc.contributor.authorRodrigues, Rodney Alexandre Ferreira
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:32:43Z
dc.date.available2019-10-06T15:32:43Z
dc.date.issued2019-01-01
dc.description.abstractMucositis is one of the commonest side effects in cancer patients undergoing treatment with radiotherapy and/or chemotherapy, and it currently lacks appropriate and effective treatment. Acmella oleracea, a species of flowering herb from South America, contains spilanthol, an alkylamide that has several pharmacological properties, including anesthetic, analgesic, and anti-inflammatory activities. Therefore, the purpose of this work was to evaluate the effect of spilanthol in intestinal mucositis in Swiss mice induced by 5-fluorouracil (5-FU), an antineoplastic agent administered systemically for the treatment of many different cancers. The repeated administration of 5-FU resulted in intestinal mucositis and consequent decreased food intake, together with weight loss, in all the animals. Daily administration of spilanthol significantly lowered the severity of intestinal mucositis, reducing histopathological changes and increasing the villus height in the animals treated with spilanthol at a dosage of 30 mg/kg (p < 0.0044) compared to a group exposed only to 5-FU. A decrease of myeloperoxidase activity was also observed in the animals treated with 30 mg/kg of spilanthol (p < 0.05), although several pro-inflammatory cytokines were not quantifiable in any group. In conclusion, the data demonstrated that spilanthol effectively reduced inflammation in a mouse model of intestinal mucositis induced by 5-FU, and that the compound might be a promising therapeutic candidate for the prevention and treatment of this condition.en
dc.description.affiliationPharmacology Anesthesiology and Therapeutics Department of Physiological Sciences Piracicaba Dental School University of Campinas
dc.description.affiliationChemical Biological and Agricultural Pluridisciplinary Research Center (CPQBA) Division of Chemistry of Natural Products University of Campinas, 999 Alexandre Cazelatto
dc.description.affiliationChemical Biological and Agricultural Pluridisciplinary Research Center (CPQBA) Division of Pharmacology and Toxicology University of Campinas
dc.description.affiliationSão Paulo State University (UNESP) Department of Biology Institute of Biosciences
dc.description.affiliationFaculty of Pharmaceutical Sciences University of Campinas
dc.description.affiliationUnespSão Paulo State University (UNESP) Department of Biology Institute of Biosciences
dc.format.extent203-209
dc.identifierhttp://dx.doi.org/10.1055/a-0715-2002
dc.identifier.citationPlanta Medica, v. 85, n. 3, p. 203-209, 2019.
dc.identifier.doi10.1055/a-0715-2002
dc.identifier.issn1439-0221
dc.identifier.issn0032-0943
dc.identifier.scopus2-s2.0-85061162524
dc.identifier.urihttp://hdl.handle.net/11449/187326
dc.language.isoeng
dc.relation.ispartofPlanta Medica
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subject5-fluorouracil
dc.subjectAcmella oleracea
dc.subjectchemotherapy
dc.subjectCompositae
dc.subjectintestinal mucositis
dc.subjectspilanthol
dc.titleSpilanthol, the Principal Alkylamide from Acmella oleracea, Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Miceen
dc.typeArtigo

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