Citrulline malate supplementation might potentiate post-exercise hypotension in hypertensives: A 24-hour analysis

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dc.contributor.authorCasonatto, J.
dc.contributor.authorCavalari, J. V.
dc.contributor.authorGoessler, K. F.
dc.contributor.authorChristofaro, D. G.D. [UNESP]
dc.contributor.authorPolito, M. D.
dc.contributor.authorEnokida, D. M.
dc.contributor.authorGrandolfi, K.
dc.contributor.institutionUniversity of Northern Paraná
dc.contributor.institutionPost-Graduation Program in Environment and Health
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2019-10-06T15:41:02Z
dc.date.available2019-10-06T15:41:02Z
dc.date.issued2019-09-01
dc.description.abstractObjective: The present study was designed to investigate whether citrulline malate supplementation might influence the acute post-exercise blood pressure response in hypertensives. Methods: Forty adults, hypertensive and sedentary, were randomly assigned to one of four experimental groups (control-placebo, control-citrulline, exercise-placebo, and exercise-citrulline). The volunteers ingested a sachet with placebo (6 grams) or citrulline malate (6 grams). During the exercise session, individuals performed 40 min of walking/running on a treadmill at 60–70% of reserve heart rate. For the control's session, they remained seated at rest for 40 min. Office blood pressure was taken every 10 min until completing 60 min after the experimental session. The ambulatory blood pressure device was programmed to take the readings every 20 min (awake time) and every 30 min (sleep time) over the course of 24 h of monitoring. Furthermore, heart rate variability was measured. Results: Considering systolic blood pressure, the aerobic exercise combined with citrulline malate supplementation promoted an additional blood pressure reduction when compared to isolated exercise during 60 min after the experimental session (−15.01 ± 2.57 mmHg vs. −6.30 ± 3.60 mmHg, P = 0.03). Additionally, considering diastolic blood pressure, exercise combined with citrulline malate showed a significant effect for the “awake” period (−13.93 ± 1.96 mmHg vs. −6.85 ± 2.57 mmHg, P = 0.027) and over the course of 24 h (−13.83 ± 1.93 mmHg vs. −7.64 ± 2.58 mmHg, P = 0.047). Conclusion: Acute citrulline malate supplementation might potentiate the post-exercise hypotension effects in hypertensive individuals.en
dc.description.affiliationResearch Group in Physiology and Physical Activity University of Northern Paraná
dc.description.affiliationPlanalto Catarinense University Post-Graduation Program in Environment and Health
dc.description.affiliationSão Paulo State University (Unesp) School of Technology and Sciences
dc.description.affiliationLondrina State University Physical Education and Sports Centre
dc.description.affiliationUnespSão Paulo State University (Unesp) School of Technology and Sciences
dc.format.extent261.e1-261.e9
dc.identifierhttp://dx.doi.org/10.1016/j.scispo.2019.03.001
dc.identifier.citationScience and Sports, v. 34, n. 4, p. 261.e1-261.e9, 2019.
dc.identifier.doi10.1016/j.scispo.2019.03.001
dc.identifier.issn1778-4131
dc.identifier.issn0765-1597
dc.identifier.scopus2-s2.0-85064652426
dc.identifier.urihttp://hdl.handle.net/11449/187586
dc.language.isoeng
dc.language.isofra
dc.relation.ispartofScience and Sports
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAmbulatory blood pressure monitoring
dc.subjectBlood pressure
dc.subjectCitrulline malate
dc.subjectDietary supplements
dc.subjectExercise
dc.subjectHypertension
dc.titleCitrulline malate supplementation might potentiate post-exercise hypotension in hypertensives: A 24-hour analysisen
dc.titleLa supplémentation en malate de citrulline pourrait potentialiser l'hypotension post-exercice chez les hypertendusfr
dc.typeArtigo
unesp.author.orcid0000-0001-5397-5694[1]

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