Loaded Ce-Ag organic-inorganic hybrids and their antibacterial activity

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dc.contributor.authorTruffault, Laurianne
dc.contributor.authorRodrigues, Danilo Fernando
dc.contributor.authorSalgado, Hérida Regida Nunes
dc.contributor.authorSantilli, Celso Valentim
dc.contributor.authorPulcinelli, Sandra Helena
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-29T08:45:01Z
dc.date.available2022-04-29T08:45:01Z
dc.date.issued2016-11-01
dc.description.abstractThere are requirements for surfaces with antibacterial properties in various technological fields. U-PEO hybrids with antibacterial properties were synthesized by the sol-gel process, incorporating combinations of cerium and silver salts at different silver molar fractions (0, 0.02, 0.05, 0.10, and 1) relative to the total amount of doped cations. The loaded hybrids were characterized by TGA, XRD, and Raman spectroscopy. Release tests were performed using UV–vis spectroscopy, and the antibacterial properties of the hybrids were studied in agar tests and turbidimetry assays. The nanostructural evolution of the hybrids during the release of the antibacterial agents was investigated by in situ SAXS. XRD results showed the presence of the AgCl crystalline phase in the loaded hybrids from a silver molar fraction of 0.05. Raman spectroscopy evidenced the interaction of silver cations with the polymeric part of the hybrid. SAXS results confirmed these interactions and showed that cerium species interacted with both organic and inorganic parts of the hybrids. The loaded U-PEO hybrids were found to release all the incorporated cerium in 1 h, while the hybrid containing 100% of silver released only 78% of the incorporated silver. All the loaded hybrids displayed antibacterial activity against the Pseudomonas aeruginosa bacterium. The antibacterial activity was found to increase with silver molar fraction. Due to its high antibacterial activity and low silver molar fraction, the loaded hybrid with silver molar fraction of 0.10 seemed to be a good compromise between efficiency, esthetic transparency, and photostability.en
dc.description.affiliationInstitute of Chemistry Physico-Chemistry Department University of São Paulo State, Rua Prof. Francisco Degni no 55, PO Box 335, Quitandinha
dc.description.affiliationSchool of Pharmaceutical Sciences Department of Drugs and Medicines University of São Paulo State, Rodovia Araraquara, Jaú km 1
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 150170/2014-9
dc.format.extent151-160
dc.identifierhttp://dx.doi.org/10.1016/j.colsurfb.2016.07.061
dc.identifier.citationColloids and Surfaces B: Biointerfaces, v. 147, p. 151-160.
dc.identifier.doi10.1016/j.colsurfb.2016.07.061
dc.identifier.issn1873-4367
dc.identifier.issn0927-7765
dc.identifier.scopus2-s2.0-84982860522
dc.identifier.urihttp://hdl.handle.net/11449/231382
dc.language.isoeng
dc.relation.ispartofColloids and Surfaces B: Biointerfaces
dc.sourceScopus
dc.subjectAntibacterial release agent
dc.subjectCerium
dc.subjectOrganic-inorganic hybrids
dc.subjectSilver
dc.subjectSol-gel process
dc.titleLoaded Ce-Ag organic-inorganic hybrids and their antibacterial activityen
dc.typeArtigo

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Artigos - Físico Química - IQ
Artigos - Fármacos e Medicamentos - FCFAR