CHRONIC TREATMENT WITH A MILD DOSE OF NaF PROMOTES DYSLIPIDEMIA IN RATS

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dc.contributor.authorChiba, Fernando Y. [UNESP]
dc.contributor.authorGarbin, Clea A. S. [UNESP]
dc.contributor.authorMattera, Maria S. L. C. [UNESP]
dc.contributor.authorMota, Max S. O. [UNESP]
dc.contributor.authorPereira, Renato F. [UNESP]
dc.contributor.authorSumida, Doris H. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T16:16:48Z
dc.date.available2018-11-26T16:16:48Z
dc.date.issued2015-07-01
dc.description.abstractExcessive fluoride ion (F) intake promotes systemic metabolic alterations, such as a decrease in insulin secretion, hyperglycemia, and insulin resistance, similar to those observed in diabetes. Cardiovascular disease is responsible for a large degree of morbidity and mortality in individuals with diabetes, and dyslipidemia is considered to be one of the most important risk factors for the development of cardiovascular disease. This study aimed to evaluate the chronic effect of NaF on insulin signal transduction in liver and in muscle, and to determine the plasma concentrations of triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and very low-density lipoprotein cholesterol (VLDL-C). Seven-week-old castrated male Wistar rats were randomly distributed into a control group, which received 76.4 mg/L NaCl in their drinking water, and a fluoride group, which received 54.9 mg/L NaF in their drinking water and F in their food pellets (estimated total F intake: 4.0 mg/kg body weight (bw)/day). After 42 days, the insulin receptor substrate-1 (IRS-1) serine phosphorylation status in the liver and muscle tissues and plasma concentrations of triglycerides, total cholesterol, HDL-C, LDL-C, VLDL-C and F were evaluated. The chronic treatment with F promoted an increase in the plasma concentrations of TG, TC, VLDL-C and F but no alteration in the plasma concentrations of HDL-C and LDLC or in the IRS-1 serine phosphorylation status in liver or muscle tissue. These results demonstrate that chronic treatment with NaF (4.0 mg/kg bw/day) promotes dyslipidemia in castrated rats but does not interfere with the IRS-1 serine phosphorylation status, one of the inhibitory pathways of the insulin signal in muscle and liver tissues.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dent Sch Aracatuba, Dept Infant & Social Dent, Aracatuba, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dent Sch Aracatuba, Dept Infant & Social Dent, Aracatuba, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipPro-Rector for Research of UNESP (PROPe-UNESP)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2010/10664-5
dc.description.sponsorshipIdFAPESP: 2013/19586-5
dc.format.extent205-212
dc.identifier.citationFluoride. Ocean View: Int Soc Fluoride Research, v. 48, n. 3, p. 205-212, 2015.
dc.identifier.issn0015-4725
dc.identifier.lattes4419158525709686
dc.identifier.orcid0000-0001-5069-8812
dc.identifier.urihttp://hdl.handle.net/11449/160801
dc.identifier.wosWOS:000361182300004
dc.language.isoeng
dc.publisherInt Soc Fluoride Research
dc.relation.ispartofFluoride
dc.relation.ispartofsjr0,429
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCholesterol
dc.subjectDiabetes mellitus
dc.subjectDyslipidemia
dc.subjectInsulin resistance
dc.subjectInsulin receptor substrate-1
dc.subjectIRS-1 serine phosphorylation status
dc.subjectTriglycerides
dc.titleCHRONIC TREATMENT WITH A MILD DOSE OF NaF PROMOTES DYSLIPIDEMIA IN RATSen
dc.typeArtigo
dcterms.rightsHolderInt Soc Fluoride Research
unesp.author.lattes4419158525709686[2]
unesp.author.orcid0000-0001-5069-8812[2]

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Artigos - Ciências Básicas - FOA
Artigos - Odontologia Infantil e Social - FOA