Ductal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 protein

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dc.contributor.authorLeal, Conceição B.
dc.contributor.authorSchmitt, Fernando C. [UNESP]
dc.contributor.authorBento, Maria J.
dc.contributor.authorMaia, Nuno C.
dc.contributor.authorLopes, Carlos S.
dc.contributor.institutionCancer Institute
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionPorto Medical School
dc.contributor.institutionIPATIMUP
dc.date.accessioned2022-04-28T19:54:16Z
dc.date.available2022-04-28T19:54:16Z
dc.date.issued1995-01-01
dc.description.abstractBackground. Ductal carcinoma in situ (DCIS) of the breast has been diagnosed increasingly since the advent of mammography. However, the natural history of these lesions remains uncertain. Ductal carcinoma in situ of the breast does not represent a single entity but a heterogeneous group with histologic and clinical differences. The histologic subtype of DCIS seems to have an influence on its biologic behavior, but there are few studies correlating subtype with biologic markers. Methods. The authors studied a consecutive series of 40 cases of DCIS and after its histologic categorization verified its relationship with ploidy using image analysis and analyzing estrogen receptor (ER), progesterone receptor (PR), p53 and c‐erbB‐2 expression using immunohistochemistry. Results. The three groups proposed according to the grade of malignancy were correlated significantly with some of the additional parameters studied, including aneuploidy and c‐erbB‐2 expression. Aneuploidy was detected in 77.5% of cases of DCIS mainly in high and intermediate grade subtypes (100% and 80% vs. 35.7% in low grade) whereas immunoreactivity for c‐erbB‐2 was detected in 45% of cases of DCIS mainly in the high grade group. Expression of ER and PR were observed frequently in this study (63.9% and 65.7% respectively), but without correlation with the histologic subtype of DCIS, although we found a somewhat significant association between high grade DCIS and lack of ER. p53 protein expression was detected in 36.8% of these cases, but no relationship between this expression and histologic subtype or grading of DCIS was found. Conclusions. These results provide further evidence for the morphologic and biologic heterogeneity of DCIS. Besides histologic classification and nuclear grading, some biologic markers such as aneuploidy and c‐erbB‐2 expression constitute additional criteria of high grade of malignancy. Copyright © 1995 American Cancer Societyen
dc.description.affiliationDepartment of Pathology Cancer Institute, Porto
dc.description.affiliationDepartment of Epidemiology Cancer Institute, Porto
dc.description.affiliationDepartment of Surgery Cancer Institute, Porto
dc.description.affiliationDepartment of Pathology Botucatu School of Medicine Universidade Estadual Paulista, Botucatu, Sã Paulo
dc.description.affiliationUnit of Molecular Pathology IPATIMUP Porto Medical School, Porto
dc.description.affiliationUnit of Molecular Pathology IPATIMUP, Porto
dc.description.affiliationUnespDepartment of Pathology Botucatu School of Medicine Universidade Estadual Paulista, Botucatu, Sã Paulo
dc.format.extent2123-2131
dc.identifierhttp://dx.doi.org/10.1002/1097-0142(19950415)75:8<2123
dc.identifier.citationCancer, v. 75, n. 8, p. 2123-2131, 1995.
dc.identifier.doi10.1002/1097-0142(19950415)75:8<2123
dc.identifier.issn1097-0142
dc.identifier.issn0008-543X
dc.identifier.scopus2-s2.0-0028952065
dc.identifier.urihttp://hdl.handle.net/11449/224002
dc.language.isoeng
dc.relation.ispartofCancer
dc.sourceScopus
dc.subjectbreast ductal carcinoma in situ (DCIS)
dc.subjectc‐erbB‐2 expression
dc.subjectDCIS subtypes
dc.subjecthormone receptors
dc.subjectp53
dc.subjectploidy
dc.titleDuctal carcinoma in situ of the breast. Histologic categorization and its relationship to ploidy and immunohistochemical expression of hormone receptors, p53, and c‐erbB‐2 proteinen
dc.typeArtigo

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