Historical and recent biological markers of exposure to fluoride

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dc.contributor.authorPessan, Juliano Pelim [UNESP]
dc.contributor.authorBuzalaf, Marília Rabelo Afonso
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:25:54Z
dc.date.available2014-05-27T11:25:54Z
dc.date.issued2011-06-01
dc.description.abstractRecent and historical biomarkers assess chronic or subchronic exposure to fluoride. The most studied recent biomarkers are nails and hair. Both can be non-invasively obtained, although collection of nails is more accepted by the subjects. External contamination may be a problem for both biomarkers and still needs to be better evaluated. Nails have been more extensively studied. Although the available knowledge does not allow their use as predictors of dental fluorosis by individual subjects, since reference values of fluoride have not yet been established, they have a strong potential for use in epidemiological surveys. Toenails should be preferred instead of fingernails, and variables that are known to affect nail fluoride concentrations - such as age, gender and geographical area - should be considered. The main historical biomarkers that could indicate total fluoride body burden are bone and dentin. Of these, bone is more studied, but its fluoride concentrations vary according to the type of bone and subjects' age and gender. They are also influenced by genetic background, renal function and remodeling rate, variables that complicate the establishment of a normal range of fluoride levels in bone that could indicate 'desirable' exposure to fluoride. The main issue when attempting to use bone as biomarker of fluoride exposure is the difficulty and invasiveness of sample collection. In this aspect, collection of dentin, especially from 3rd molars that are commonly extracted, is advantageous. However, mean values also span a wide range and reference concentrations have not been published yet. © 2011 S. Karger AG, Basel.en
dc.description.affiliationDepartment of Pediatric Dentistry and Public Health Araçatuba Dental School São Paulo State University, Rua José Bonifácio, 1193, 16015-050 Araçatuba - SP
dc.description.affiliationDepartment of Biological Sciences Bauru Dental School University of São Paulo, Bauru
dc.description.affiliationUnespDepartment of Pediatric Dentistry and Public Health Araçatuba Dental School São Paulo State University, Rua José Bonifácio, 1193, 16015-050 Araçatuba - SP
dc.format.extent52-65
dc.identifierhttp://dx.doi.org/10.1159/000325145
dc.identifier.citationMonographs in Oral Science, v. 22, p. 52-65.
dc.identifier.doi10.1159/000325145
dc.identifier.issn0077-0892
dc.identifier.issn1662-3843
dc.identifier.scopus2-s2.0-79960213940
dc.identifier.urihttp://hdl.handle.net/11449/72467
dc.language.isoeng
dc.relation.ispartofMonographs in Oral Science
dc.relation.ispartofsjr2,017
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectanticaries agent
dc.subjectbiological marker
dc.subjectfluoride
dc.subjectbody burden
dc.subjectbone
dc.subjectchemistry
dc.subjectdentin
dc.subjecthair
dc.subjecthuman
dc.subjectnail
dc.subjectBiological Markers
dc.subjectBody Burden
dc.subjectBone and Bones
dc.subjectCariostatic Agents
dc.subjectDentin
dc.subjectFluorides
dc.subjectHair
dc.subjectHumans
dc.subjectNails
dc.titleHistorical and recent biological markers of exposure to fluorideen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/RightsPermissions
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Odontologia Infantil e Social - FOA