Antinociceptive effect of amitraz in mice and rats

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dc.contributor.authorQueiroz-Neto, A. [UNESP]
dc.contributor.authorJuang, S. J. [UNESP]
dc.contributor.authorSouza, K. R. [UNESP]
dc.contributor.authorAkamatsu, A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:54:01Z
dc.date.available2022-04-28T19:54:01Z
dc.date.issued1994-01-01
dc.description.abstractAmitraz, a formamidine insecticide and acaricide used in veterinary practice, presents side effects related to its pharmacological activity on α2-adrenergic receptors. The present study was undertaken to investigate the antinociceptive effect of amitraz in rats and mice. The tail-flick test was used to determine the duration of the antinociceptive effect of the intraperitoneal (ip) administration of amitraz (1 and 2 mg/kg, 10 animals per group) in male Wistar rats weighing 180-220 g. The writhing test (using 10 ml/kg of a 0.6% acetic acid solution as a painful stimulus) was performed in 140 male Swiss mice weighing 20-30 g, divided into 14 groups that received ip injections of saline, amitraz (0.5, 1.0, 1.5, 2.0 and 4.0 mg/kg), xylazine or detomidine (1.0, 1.5, 2.0 and 4.0 mg/kg), in order to compare the effect of amitraz to that caused by xylazine and detomidine, and to investigate the participation of α2-adrenergic receptors which were blocked by idazoxan (1 mg/kg). Amitraz induced a significant antinociceptive effect in both rats and mice. This effect is blocked in mice by idazoxan.en
dc.description.affiliationDpto. Morfologia/Fisiologia Animal Fac. Ciencias Agrarias/Veterinarias UNESP, 14870-000 Jaboticabal, SP
dc.description.affiliationUnespDpto. Morfologia/Fisiologia Animal Fac. Ciencias Agrarias/Veterinarias UNESP, 14870-000 Jaboticabal, SP
dc.format.extent1407-1411
dc.identifier.citationBrazilian Journal of Medical and Biological Research, v. 27, n. 6, p. 1407-1411, 1994.
dc.identifier.issn0100-879X
dc.identifier.scopus2-s2.0-0028233633
dc.identifier.urihttp://hdl.handle.net/11449/223977
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.sourceScopus
dc.subjectα2-adrenergic agonists
dc.subjectamitraz
dc.subjectantinociceptive effect
dc.subjectdetomidine
dc.subjectidazoxan
dc.subjecttail flick test
dc.subjectwrithing test
dc.subjectxylazine
dc.titleAntinociceptive effect of amitraz in mice and ratsen
dc.typeArtigo

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Artigos - Morfologia e Fisiologia Animal - FCAV