HYPOTHALAMIC-LESIONS INCREASE SALINE INGESTION INDUCED BY INJECTION OF ANGIOTENSIN-II INTO AV3V IN RATS

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dc.contributor.authorCamargo, LAD
dc.contributor.authorSaad, W. A.
dc.contributor.authorRenzi, Antonio [UNESP]
dc.contributor.authorDeluca, L. A.
dc.contributor.authorGONCALVES, JR
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:20:54Z
dc.date.available2014-05-20T15:20:54Z
dc.date.issued1991-09-01
dc.description.abstractWater and 3% NaCl intake were increased by the injection of 4 ng angiotensin II (ANG II) into the anteroventral third ventricle (AV3V) region of rats. Pretreatment with two specific ANG II receptor antagonists, [octanoyl-Leu8]ANG II and [Leu8]ANG II, significantly reduced ANG II-induced water and saline intake. This inhibition lasted approximately 30 min, with partial recovery at 60 min. In rats with electrolytic lesion of the bilateral ventromedial nucleus of hypothalamus (VMH), the effect of ANG II on water intake was not different from that observed in sham rats, but saline ingestion increased. In summary, the present results show that the AV3V region is an important central structure for ANG II-induced saline ingestion. Lesion of the VMH increases the response to ANG II, showing an interaction between the AV3V region and the VMH in the regulation of salt ingestion.en
dc.description.affiliationPAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,1680 HUMAITA ST,BR-14800 ARARAQUARA,SP,BRAZIL
dc.description.affiliationUnespPAULISTA STATE UNIV,SCH DENT,DEPT PHYSIOL,1680 HUMAITA ST,BR-14800 ARARAQUARA,SP,BRAZIL
dc.format.extentR647-R651
dc.identifierhttp://ajpregu.physiology.org/content/261/3/R647
dc.identifier.citationAmerican Journal of Physiology. Bethesda: Amer Physiological Soc, v. 261, n. 3, p. R647-R651, 1991.
dc.identifier.issn0002-9513
dc.identifier.lattes6551236936295697
dc.identifier.lattes1548626194113665
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/32099
dc.identifier.wosWOS:A1991GE63800067
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSALT INGESTIONpt
dc.subjectWATER INGESTIONpt
dc.subjectANGIOTENSIN-II ANTAGONISTSpt
dc.titleHYPOTHALAMIC-LESIONS INCREASE SALINE INGESTION INDUCED BY INJECTION OF ANGIOTENSIN-II INTO AV3V IN RATSen
dc.typeArtigo
dcterms.licensehttp://www.the-aps.org/mm/Publications/Info-For-Authors/Copyright
dcterms.rightsHolderAmer Physiological Soc
unesp.author.lattes6551236936295697
unesp.author.lattes1548626194113665
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[6]
unesp.author.orcid0000-0001-8270-2652[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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