Effects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferens

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dc.contributor.authorCampos, M.
dc.contributor.authorMorais, P. D.
dc.contributor.authorPupo, A. S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:48:59Z
dc.date.available2014-05-20T13:48:59Z
dc.date.issued2003-06-20
dc.description.abstractThe contractions of the rat vas deferens in response to noradrenaline are mediated through alpha(1A)-adrenoceptors. We observed participation of alpha(1B)-adrenoceptors in these contractions after castration. We now investigated the time course of this plasticity and the effects of testosterone by determining the actions of competitive antagonists on noradrenaline-induced contractions after 7, 14, 21 and 30 days of castration. BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride) antagonised noradrenaline-induced contractions in control and castrated rats with low pA(2) values (congruent to 6.8). In control vas deferens, WB 4101 (2-(2,6-dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane hydrochloride) had a slope in the Schild plot no different from 1.0, while slopes lower than 1.0 ( approximate to 0.6) were observed for vas deferens from castrated rats. Chloroethylclonidine was ineffective in the control vas while it inhibited noradrenaline-induced contractions in vasa from castrated rats and converted the complex antagonism by WB 4101 into simple competitive antagonism. Treatment of castrated rats with testosterone prevented the effects of castration. The results suggest that alpha(1B)-adrenoceptors are detectable in vas deferens from at least the 7th through the 30th day after castration and that testosterone prevents this plasticity. (C) 2003 Elsevier B.V. B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Inst Biociencias, Dept Farmacol, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Inst Biociencias, Dept Farmacol, BR-18618000 Botucatu, SP, Brazil
dc.format.extent149-155
dc.identifierhttp://dx.doi.org/10.1016/S0014-2999(03)01822-3
dc.identifier.citationEuropean Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 471, n. 2, p. 149-155, 2003.
dc.identifier.doi10.1016/S0014-2999(03)01822-3
dc.identifier.issn0014-2999
dc.identifier.lattes2224433126054725
dc.identifier.urihttp://hdl.handle.net/11449/17437
dc.identifier.wosWOS:000183792800010
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofEuropean Journal of Pharmacology
dc.relation.ispartofjcr3.040
dc.relation.ispartofsjr1,057
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectalpha(1)-adrenoceptorpt
dc.subjectvas deferenspt
dc.subject(rat)pt
dc.subjectcastrationpt
dc.subjecttestosteronept
dc.titleEffects of castration and of testosterone replacement on alpha(1)-adrenoceptor subtypes in the rat vas deferensen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2224433126054725[3]
unesp.author.orcid0000-0003-3571-7215[1]
unesp.author.orcid0000-0001-6627-3448[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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