Multichannel AC Biosusceptometry System to Map Biodistribution and Assess the Pharmacokinetic Profile of Magnetic Nanoparticles by Imaging

Página do item simplificado
dc.contributor.authorSoares, Guilherme A. [UNESP]
dc.contributor.authorProspero, Andre G. [UNESP]
dc.contributor.authorCalabresi, Marcos F. [UNESP]
dc.contributor.authorRodrigues, Diego S.
dc.contributor.authorSimoes, Luis G. [UNESP]
dc.contributor.authorQuini, Caio C. [UNESP]
dc.contributor.authorMatos, Ronaldo R. [UNESP]
dc.contributor.authorPinto, Leonardo A. [UNESP]
dc.contributor.authorSousa-Junior, Ailton A.
dc.contributor.authorBakuzis, Andris F.
dc.contributor.authorMancera, Paulo A. [UNESP]
dc.contributor.authorMiranda, Jose R. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionICEx
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.date.accessioned2019-10-06T16:26:57Z
dc.date.available2019-10-06T16:26:57Z
dc.date.issued2019-07-01
dc.description.abstractIn this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic nanoparticles in both bloodstream clearance and liver accumulation, where a complex network of inter-related cells is responsible for MNP uptake. Based on the acquired MC-ACB images, we propose a mathematical model which helps to understand the distribution and accumulation pharmacokinetics of MNP. The MC-ACB showed a high time resolution to detect and monitor MNP, providing sequential images over the particle biodistribution. Utilizing the MC-ACB instrument, we assessed regions corresponding to the heart and liver, and we determined the MNP transfer rates between the bloodstream and the liver. The pharmacokinetic model resulted in having a strong correlation with the experimental data, suggesting that the MC-ACB is a valuable and accessible imaging device to assess in vivo and real-time pharmacokinetic features of MNP.en
dc.description.affiliationDepartamento de Física e Biofísica UNESP/São Paulo State University-Laboratório de Biomagnetismo
dc.description.affiliationUNIFAL-MG/Universidade Federal de Alfenas-MG-Departamento de Física ICEx
dc.description.affiliationInstituto de Física Universidade Federal de Goiás
dc.description.affiliationUNESP/São Paulo State University-Departamento de Bioestatística IBB
dc.description.affiliationUnespDepartamento de Física e Biofísica UNESP/São Paulo State University-Laboratório de Biomagnetismo
dc.description.affiliationUnespUNESP/São Paulo State University-Departamento de Bioestatística IBB
dc.format.extent456-462
dc.identifierhttp://dx.doi.org/10.1109/TNB.2019.2912073
dc.identifier.citationIEEE Transactions on Nanobioscience, v. 18, n. 3, p. 456-462, 2019.
dc.identifier.doi10.1109/TNB.2019.2912073
dc.identifier.issn1536-1241
dc.identifier.lattes8232289412108723
dc.identifier.orcid0000-0002-2080-8053
dc.identifier.scopus2-s2.0-85064653690
dc.identifier.urihttp://hdl.handle.net/11449/189012
dc.language.isoeng
dc.relation.ispartofIEEE Transactions on Nanobioscience
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectac biosusceptometry
dc.subjectmagnetic imaging
dc.subjectMagnetic nanoparticles
dc.subjectpharmacokinetic model
dc.titleMultichannel AC Biosusceptometry System to Map Biodistribution and Assess the Pharmacokinetic Profile of Magnetic Nanoparticles by Imagingen
dc.typeArtigo
unesp.author.lattes8232289412108723[11]
unesp.author.orcid0000-0002-0016-1715[1]
unesp.author.orcid0000-0002-6037-6064[8]
unesp.author.orcid0000-0001-8216-2043[9]
unesp.author.orcid0000-0003-3366-106X[10]
unesp.author.orcid0000-0002-2080-8053[11]

Arquivos

Coleções

Artigos - Bioestatística - IBB