Now showing items 1-10 of 93
Aberrant crypt foci and colon cancer: comparison between a short- and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats
(Brazilian Journal of Medical and Biological Research, 2002-03-01) [Artigo]
Aberrant crypt foci (ACF) in the colon of carcinogen-treated rodents are considered to be the earliest hallmark of colon carcinogenesis. In the present study the relationship between a short-term (4 weeks) and medium-term ...
Lycopene activity against chemically induced DNA damage in Chinese hamster ovary cells
(Toxicology in Vitro, 2007-08-01) [Artigo]
Lycopene is a natural pigment synthesized by plants and microorganisms, and it is mainly found in tomatoes. It is an acyclic isomer of P-carotene and one of the most potent antioxidants. Several studies have demonstrated ...
DNA damage in cytologically normal urothelial cells of patients with a history of urothelial cell carcinoma
(Environmental and Molecular Mutagenesis, 2002-01-01) [Artigo]
In order to determine if patients with a history of previous urothelial cell carcinoma (UCC) but with current normal urinary cytology have DNA damage in urothelial cells, the single-cell gel electrophoresis (comet) assay ...
Mutagenic and carcinogenic potential of a textile azo dye processing plant effluent that impacts a drinking water source
(Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 2007-01-10) [Artigo]
Recently a textile azo dye processing plant effluent was identified as one of the sources of mutagenic activity detected in the Cristais River, a drinking water source in Brazil [G.A. Umbuzeiro, D.A. Roubicek, C.M. Rech, ...
No mutations found in the exon 2 of p16 INK4a and K-ras
(Oral Oncology, 2009-07-01) [Resumo]
Farming technology, biochemistry characterization, and protective effects of culinary-medicinal mushrooms Agaricus brasiliensis S. Wasser et al. and Lentinus edodes (Berk.) Singer: Five years of research in Brazil
(International Journal of Medicinal Mushrooms, 2005-07-04) [Artigo]
The biotechnology, biochemical characterization, and protective effects of the himematsutake and shiitake mushrooms were studied for the Thematic Project, from 1998 to 2003. A new species, Agaricus Brasiliens is Wasser et ...
Genotoxicity of cigarette smoking in maternal and newborn lymphocytes
(Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 2009-09-01) [Artigo]
Tobacco smoke contains a large number of substances known to induce DNA damage and to be hazardous to human health. Several reviews and meta-analyses have reported an association between maternal or paternal smoking habits ...
No relationship between subchronic fluoride intake and DNA damage in Wistar rats
(Caries Research, 2004-01-01) [Artigo]
Fluoride has been widely used in dentistry because it is an effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury on the genetic apparatus. ...
Does toxoplasmosis cause DNA damage? An evaluation in isogenic mice under normal diet or dietary restriction
(Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 2004-04-11) [Artigo]
Toxoplasmosis is an anthropozoonotic widespread disease, caused by the coccidian protozoan parasite Toxoplasma gondii. Since there are no data regarding the genotoxicity of the parasite in vivo, this study was designed to ...
Use of comet assay to assess DNA damage in patients infected by Helicobacter pylori - Comparisons between visual and image analyses
(Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 2005-09-05) [Artigo]
Studies of DNA damage in gastric epithelial cells of Helicobacter pylori (H. pylori)-infected patients are conflicting, possibly due to different methods used for scoring DNA damage by Comet assay. Therefore, we compared ...