Now showing items 1-10 of 18
Effects of diuron on toxicological and hematological parameters and lymphohematopoietic organs in a rat chemical hepatocarcinogenesis model
(Annual Review of Biomedical Sciences, 2005) [Artigo]
Lack of chemoprevention of dietary Agaricus blazei against rat colonic aberrant crypt foci
(Human & Experimental Toxicology, 2008-06-01) [Artigo]
The mushroom Agaricus blazei (Ab) has been widely used in folk medicine to treat various diseases including cancer. No information is available on its possible protective effects on the development of colon cancer. The ...
Genotoxicity of cigarette smoking in maternal and newborn lymphocytes
(Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 2009-09-01) [Artigo]
Tobacco smoke contains a large number of substances known to induce DNA damage and to be hazardous to human health. Several reviews and meta-analyses have reported an association between maternal or paternal smoking habits ...
Screening for In Vitro and In Vivo Antitumor Activities of the Mushroom Agaricus Blazei
(Nutrition and Cancer-an International Journal, 2009-01-01) [Artigo]
We have investigated the in vitro antitumor activity of the mushroom Agaricus blazei Murill on human cancer cell lines as well as its potential anticancer activity in a model of rat colon carcinogenesis. The in vitro ...
Imbalance of Tumor Suppression Genes Expression Following Rat Tongue Carcinogenesis Induced by 4-Nitroquinoline 1-Oxide
(In Vivo, 2009-11-01) [Artigo]
This study was undertaken to investigate, by immunohistochemistry, the expression of some tumor suppressor genes such asp 16, p21 and Retinoblastoma (Rb) during 4-Nitroquinoline I-oxide induced rat tongue carcinogenesis. ...
Lack of Chemopreventive Activity of Agaricus blazei Mushroom on the Development of 1,2-Dimethylhydrazine-Induced Colonic Aberrant Crypt Foci in Rats
(Nutrition and Cancer-an International Journal, 2008-01-01) [Artigo]
Chemopreventive and immunomodulatory potential of methanolic (MET) and dichloromethanic (DCl) extracts of Agaricus blazei mushroom were investigated in the postinitiation stage of colon carcinogenesis in male Wistar rats. ...
Quantitative real-time RT-PCR and chromogenic in situ hybridization: precise methods to detect HER-2 status in breast carcinoma
(BMC Cancer, 2009-03-23) [Artigo]
Background: HER-2 gene testing has become an integral part of breast cancer patient diagnosis. The most commonly used assay in the clinical setting for evaluating HER-2 status is immunohistochemistry (IHC) and fluorescence ...
Polysaccharide fraction of Agaricus brasiliensis avoids tumor-induced IL-10 production and changes the microenvironment of subcutaneous Ehrlich adenocarcinoma
(Cellular Immunology, 2009-01-01) [Artigo]
Subcutaneous Ehrlich tumor-bearing mice were treated with in situ inoculation of a P-glucan-rich extract of Agaricus brasiliensis (ATF), which reduced tumor growth. Histopathological analysis showed that the tumor masses ...
Genomic instability in blood cells is able to predict the oral cancer risk: an experimental study in rats
(Journal of Molecular Histology, 2008-10-01) [Artigo]
This study was undertaken to investigate the genomic instability on blood cells during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis by means of single cell gel (comet) and micronucleus assays. Male ...
beta-Glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2
(Archives of Toxicology, 2009-01-01) [Artigo]
The mushroom Agaricus blazei is studied for its nutraceutical potential and as a medicinal supplement. The aim of the present study was to investigate the chemoprotective effect of beta-glucan extracted from the mushroom ...