Now showing items 1-10 of 49
NO EVIDENCE of PATHOLOGICAL AUTOIMMUNITY FOLLOWING MYCOBACTERIUM LEPRAE HEAT-SHOCK PROTEIN 65-DNA VACCINATION IN MICE
(European Journal of Inflammation, 2009-05-01) [Artigo]
Heat-shock proteins (HSPs) are currently one of the most promising targets for the development of immunotherapy against tumours and autoimmune disorders. This protein family has the capacity to activate or modulate the ...
BCG and BCG/DNAhsp65 Vaccinations Promote Protective Effects without Deleterious Consequences for Experimental Autoimmune Encephalomyelitis
(Clinical & Developmental Immunology, 2013-01-01) [Artigo]
A prime-boost strategy conserving BCG is considered the most promising vaccine to control tuberculosis. A boost with a DNA vaccine containing the mycobacterial gene of a heat shock protein (pVAXhsp65) after BCG priming ...
Genetic vaccine for tuberculosis (pVAXhsp65) primes neonate mice for a strong immune response at the adult stage
(Genetic Vaccines and Therapy, 2007-11-29) [Artigo]
Background: Vaccination of neonates is generally difficult due to the immaturity of the immune system and consequent higher susceptibility to tolerance induction. Genetic immunization has been described as an alternative ...
Th1 polarized response induced by intramuscular DNA-HSP65 immunization is preserved in experimental atherosclerosis
(Brazilian Journal of Medical and Biological Research, 2007-11-01) [Artigo]
We previously reported that a DNA vaccine constructed with the heat shock protein (HSP65) gene from Mycobacterium leprae (DNA-HSP65) was protective and also therapeutic in experimental tuberculosis. By the intramuscular ...
Is the BCG Vaccine Safe for Undernourished Individuals?
(Clinical & Developmental Immunology, 2012-01-01) [Artigo]
Cellular immunity is critical for protection against tuberculosis, but its integrity is compromised during undernutrition. The present study was designed to evaluate if the attenuated mycobacterium BCG is a safe vaccine ...
Migratory route of Strongyloides venezuelensis in Lewis rats: Comparison of histological analyses and PCR
(Experimental Parasitology, 2011-02-01) [Artigo]
Strongyloides venezuelensis is a parasitic nematode that has been used as a model to study human and animal strongyloidiasis. In this study, we compared the sensitivity between traditional methodologies and PCR assay to ...
Recovery from Strongyloides venezuelensis infection in Lewis rats is associated with a strong Th2 response
(Parasite Immunology, 2010-01-01) [Artigo]
P>In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs ...
Tolerance induction by co-immunization with dnahsp65 and recombinant hsp65 did not avoid full experimental encephalomyelitis evolution
(Inflammation Research, 2011-06-01) [Resumo]
Immunization with pVAXhsp65 Decreases Inflammation and Modulates Immune Response in Experimental Encephalomyelitis
(Neuroimmunomodulation, 2010-01-01) [Artigo]
Background: A DNA vaccine (pVAXhsp65) containing the gene of a heat-shock protein (hsp65) from Mycobacterium leprae showed high immunogenicity and protective efficacy against tuberculosis in BALB/c mice. A possible deleterious ...
Downmodulation of peripheral MUG-specific immunity by pVAXhspe65 treatment during EAE does not reach the CNS
(Journal of Neuroimmunology, 2014-03-15) [Artigo]
Most of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic ...