Now showing items 1-10 of 30
Analysis of CDKN1A polymorphisms: markers of cancer susceptibility?
(Cancer Genetics and Cytogenetics, 2003-04-15) [Artigo]
The CDKN1A (TP21)(2) gene encodes a 21-kD protein that is a critical downstream mediator of wild-type TP53 and an important regulator of the cell cycle. Failure in the function of this gene would be expected to result in ...
HFE gene mutations in Brazilian thalassemic patients
(Brazilian Journal of Medical and Biological Research, 2006-12-01) [Artigo]
Hereditary hemochromatosis is a disorder of iron metabolism characterized by increased iron intake and progressive storage and is related to mutations in the HFE gene. Interactions between thalassemia and hemochromatosis ...
Analysis of human papillomavirus prevalence and TP53 polymorphism in head and neck squamous cell carcinomas
(Cancer Genetics and Cytogenetics, 2004-04-01) [Artigo]
Head and neck squamous cell carcinoma is a disease associated with tobacco and alcohol abuse. There is evidence that the oncogenic human papillomavirus (HPV) may also be a risk for upper aerodigestive tract cancers. High-risk ...
Methylation profile of genes CDKN2A (p14 and p16), DAPK1, CDH1, and ADAM23 in head and neck cancer
(Cancer Genetics and Cytogenetics, 2007-02-01) [Artigo]
Hypermethylation in the promoter region has been associated with a loss of gene function that may give a selective advantage to neoplastic cells. In this study, the methylation pattern of genes CDKN2A (alias p14, p14(ARF), ...
Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma
(Oncology Reports, 2009-03-01) [Artigo]
Laryngeal squamous cell carcinoma is very common in head and neck cancer, with high mortality rates and poor prognosis. In this study, we compared expression profiles of clinical samples from 13 larynx tumors and 10 ...
Molecular models of NS3 protease variants of the Hepatitis C virus
(Bmc Structural Biology, 2005-01-21) [Artigo]
Background: Hepatitis C virus (HCV) currently infects approximately three percent of the world population. In view of the lack of vaccines against HCV, there is an urgent need for an efficient treatment of the disease by ...
Saint Louis encephalitis virus, Brazil
(Emerging Infectious Diseases, 2007-01-01) [Carta]
A transcript finishing initiative for closing gaps in the human transcriptome
(Genome Research, 2004-07-01) [Artigo]
We report the results of a transcript finishing initiative, undertaken for the purpose of identifying and characterizing novel human transcripts, in which RT-PCR was used to bridge gaps between paired EST Clusters, mapped ...
Positive selection results in frequent reversible amino acid replacements in the G protein gene of human respiratory syncytial virus
(PLoS Pathogens, 2009-01-01) [Artigo]
Human respiratory syncytial virus (HRSV) is the major cause of lower respiratory tract infections in children under 5 years of age and the elderly, causing annual disease outbreaks during the fall and winter. Multiple ...
Quasispecies of hepatitis C virus genotype 1 and treatment outcome with Peginterferon and Ribavirin
(Infection, Genetics and Evolution, 2009-07-01) [Trabalho apresentado em evento]
The majority of patients with chronic hepatitis C fail to respond to antiviral therapy. The genetic basis of this resistance is unknown. The quasispecies nature of HCV may have an important implication concerning viral ...