Now showing items 1-4 of 4
4 '-Aminochalcones As Novel Inhibitors of the Chlorinating Activity of Myeloperoxidase
(Current Medicinal Chemistry, 2012-11-01) [Resenha]
The excessive activation of neutrophils generates reactive oxygen species (ROS) and the secretion of primary granular enzymes, such as myeloperoxidase (MPO), which is implicated in numerous inflammatory diseases. The aim ...
Molecular hybridization: A useful tool in the design of new drug prototypes
(Current Medicinal Chemistry, 2007-07-01) [Resenha]
Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hyrid compound with improved affinity and ...
New anti-Alzheimer drugs from biodiversity: the role of the natural acetylcholinesterase inhibitors
(Mini-Reviews in Medicinal Chemistry, 2005-10-01) [Resenha]
Alzheimer's disease (AD) is a progressive neurodegenerative pathology with severe economic and social impact. There is currently no cure, although cholinesterase inhibitors provide effective temporary relief of symptoms ...
Alkyl Hydroxybenzoic Acid Derivatives that Inhibit HIV-1 Protease Dimerization
(Current Medicinal Chemistry, 2012-09-01) [Resenha]
The therapeutic potential of gallic acid and its derivatives as anti-cancer, antimicrobial and antiviral agents is well known. We have examined the mechanism by which natural gallic acid and newly synthesized gallic acid ...