Now showing items 1-10 of 71
Antimicrobial activity of Piper arboreum and Piper tuberculatum (Piperaceae) against opportunistic yeasts
(African Journal of Biotechnology, 2009-06-17) [Artigo]
In the scope of our ongoing research on bioactive agents from natural sources, 24 extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. ( Piperaceae) were screened for antifungal activity ...
Cytotoxicity of doxorubicin-loaded PLGA and PLGA-PEI nanoparticles: relevance for anti-tumor effects and cardiotoxicity
(European Journal Of Clinical Investigation, 2018-06-01) [Resumo]
Context-specific modulation of cocaine-induced locomotor sensitization and ERK and CREB phosphorylation in the rat nucleus accumbens
(European Journal of Neuroscience, 2009-11-01) [Artigo]
Learned associations are hypothesized to develop between drug effects and contextual stimuli during repeated drug administration to produce context-specific sensitization that is expressed only in the drug-associated ...
Antidiabetic activity of Musa x paradisiaca extracts in streptozotocin-induced diabetic rats and chemical characterization by HPLC-DAD-MS
(Journal Of Ethnopharmacology, 2020-05-23) [Artigo]
Ethnopharmacological relevance: The Musa x paradisiaca L. inflorescence, known as banana blossom or banana heart, is used in traditional medicine for the treatment of diabetes mellitus. Aim of the study: The aim of the ...
Synthesis, ex Vivo and in Vitro Hydrolysis Study of an Indoline Derivative Designed as an Anti-Inflammatory with Reduced Gastric Ulceration Properties
(Molecules, 2009-09-01) [Artigo]
The compound 1-(2,6-dichlorophenyl)indolin-2-one (1), planned as a pro-drug of diclofenac (2), was easily synthesized in 94% yield by an intramolecular reaction in the presence of coupling agent (i.e., EDC). Compound 1 ...
Biocompatible Microemulsion Modifies the Tissue Distribution of Doxorubicin
(Journal Of Pharmaceutical Sciences, 2014-10-01) [Artigo]
The incorporation of doxorubicin (DOX) in a microemulsion (DOX-ME) has shown beneficial consequences by reducing the cardiotoxic effects of DOX. The aim of this study was to determine the distribution of DOX-ME in Ehrlich ...
Pharmacological Evaluation and Preliminary Pharmacokinetics Studies of a New Diclofenac Prodrug without Gastric Ulceration Effect
(International Journal of Molecular Sciences, 2012-11-01) [Artigo]
Long-term nonsteroidal anti-inflammatory drugs (NSAIDs) therapy has been associated with several adverse effects such as gastric ulceration and cardiovascular events. Among the molecular modifications strategies, the prodrug ...
Preparation of FTO/CU2O Electrode Protected by PEDOT:PSS and Its Better Performance in the Photoelectrocatalytic Reduction of CO2 to Methanol
(Electrocatalysis, 2020-06-25) [Artigo]
Copper(I) oxide (Cu2O) was electrochemically deposited on fluorine-doped tin oxide (FTO) glass electrode and covered with a thin layer of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS). The electrode ...
rastreamento histoquímico, fitoquímico e biológico de folhas de Plinia cauliflora (DC.) Kausel (Myrtaceae)
(Brazilian Journal of Pharmacognosy, 2010-01-01) [Artigo]
In this work, chemical and biological activities of crude extracts obtained with 50% ethanol, 70% ethanol, acetone:water (7:3; v/v) and chloroform of Plinia cauliflora (DC.) Kausel, Myrtaceae, leaves, a native tree from ...
Total polyphenols from Syzygium cumini (L.) Skeels fruit extract
(Brazilian Journal of Pharmaceutical Sciences, 2009-01-01) [Artigo]
A precise, accurate and low cost spectrophotometric method was developed and validated for routine determination of total polyphenols, as pyrogallic acid equivalents, from the percolated and lyophilized extract of Syzygium ...