Informamos que as validações de submissão estarão suspensas de 20/12/2019 a 05/01/2020, devido ao recesso de final de ano
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Now showing items 1-10 of 125
Assessment of the chemopreventive effect of casearin B, a clerodane diterpene extracted from Casearia sylvestris (Salicaceae)
(Food and Chemical Toxicology, 2013-03-01) [Artigo]
Studies have shown that Casearia sylvestris compounds protect DNA from damage both in vitro and in vivo. Complementarily, the aim of the present study was to assess the chemopreventive effect of casearin B (CASB) against ...
Animal models of alcohol and drug dependence
(Revista Brasileira de Psiquiatria, 2013) [Artigo]
Drug addiction has serious health and social consequences. In the last 50 years, a wide range of techniques have been developed to model specific aspects of drug-taking behaviors and have greatly contributed to the ...
Analysis of rocuronium in human plasma by liquid chromatography-tandem mass spectrometry with application in clinical pharmacokinetics
(Journal of Pharmaceutical and Biomedical Analysis, 2014-03-05) [Artigo]
Rocuronium (ROC) is a neuromuscular blocking agent used in surgical procedures which is eliminated primarily by biliary excretion. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated ...
Role of nitric oxide in the periaqueductal gray in defensive behavior in mice: influence of prior local N-methyl-D-aspartate receptor activation and aversive condition
(Psychology & Neuroscience, 2010-06-01) [Artigo]
Glutamate N-methyl-D-aspartate (NMDA) receptor activation within the dorsal column of the periaqueductal gray (dPAG) leads to antinociceptive, autonomic, and behavioral responses characterized as the fear reaction. Activation ...
Leishmanicidal Activities of Novel Synthetic Furoxan and Benzofuroxan Derivatives
(Antimicrobial Agents and Chemotherapy, 2014-08-01) [Artigo]
A novel series of furoxan (1,2,5-oxadiazole 2-oxide) (compounds 3, 4a and -b, 13a and -b, and 14a to -f) and benzofuroxan (benzo[c][1,2,5] oxadiazole 1-oxide) (compounds 7 and 8a to -c) derivatives were synthesized, ...
Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning
(European Journal of Neuroscience, 2013-07-01) [Artigo]
The insular cortex (IC) has been reported to be involved in the modulation of memory and autonomic and defensive responses. However, there is conflicting evidence about the role of the IC in fear conditioning. To explore ...
Cannabidiol administration into the bed nucleus of the stria terminalis alters cardiovascular responses induced by acute restraint stress through 5-HT1A receptor
(European Neuropsychopharmacology, 2013-09-01) [Artigo]
Systemic administration of cannabidiol (CBD) is able to attenuate cardiovascular responses to acute restraint stress through activation of 5-HT1A receptors. Previous results from our group suggest that the bed nucleus of ...
Influence of the dopaminergic system, CREB, and transcription factor-B on cocaine neurotoxicity
(Brazilian Journal of Medical and Biological Research, 2013-11-01) [Artigo]
Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. ...
Antimicrobial activity of Pterogyne nitens Tul., Fabaceae, against opportunistic fungi
(Revista Brasileira de Farmacognosia, 2010-11-01) [Artigo]
No contexto de nossas pesquisas por novos agentes antifúngicos obtidos da flora brasileira, oito extratos e doze frações de Pterogyne nitens Tul., Fabaceae, foram submetidos ao ensaio antifúngico pelo método de microdiluição, ...
Controle de qualidade da raiz de Operculina macrocarpa (Linn) Urb., Convolvulaceae
(Brazilian Journal of Pharmacognosy, 2010-01-01) [Artigo]
Considering the quality of the phytotherapic agents, it is important to point out that it includes rigorous attendance of the different steps of the development and production of these products, from the collection of the ...