Logo do repositório
 

GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population

Página do item simplificado
dc.contributor.authorColombo, Jucimara [UNESP]
dc.contributor.authorRossit, Andreéa Regina Baptista
dc.contributor.authorCaetano, Alaor
dc.contributor.authorBorim, Aldenis Albaneze
dc.contributor.authorWornrath, Durval
dc.contributor.authorSilva, Ana Elizabete [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionFundação Pio XII
dc.date.accessioned2014-05-27T11:21:04Z
dc.date.available2014-05-27T11:21:04Z
dc.date.issued2004-05-01
dc.description.abstractAim: To test the hypothesis that, in the Southeastern Brazilian population, the GSTT1, GSTM1 and CYP2E1 polymorphisms and putative risk factors are associated with an increased risk for gastric cancer. Methods: We conducted a study on 100 cases of gastric cancer (GC), 100 cases of chronic gastritis (CG), and 150 controls (C). Deletion of the GSTT1 and GSTM1 genes was assessed by multiplex PCR. CYP2E1/PstI genotyping was performed using a PCR-RFLP assay. Results: No relationship between GSTT1/GSTM1 deletion and the c1/c2 genotype of CYP2E1 was observed among the three groups. However, a significant difference between CG and C was observed, due to a greater number of GSTT1/GSTM1 positive genotypes in the CG group. The GSTT1 null genotype occurred more frequently in Negroid subjects, and the GSTM1 null genotype in Caucasians, while the GSTM1 positive genotype was observed mainly in individuals with chronic gastritis infected with H pylori. Conclusion: Our findings indicate that there is no obvious relationship between the GSTT1, GSTM1 and CYP2E1 polymorphisms and gastric cancer. Copyright © 2004 by The WJG Press.en
dc.description.affiliationDepartamento de Biologia UNESP Campus de São do Rio Preto, Rua Cristovão, Colombo 2265, 15054-000 - Sao Jose do Rio Preto
dc.description.affiliationDept. de Doencas Dermatol. Infecc. Faculdade de Medicina FAMERP, Sao Jose do Rio Preto, SP
dc.description.affiliationHospital de Base Faculdade de Medicina FAMERP, Sao Jose do Rio Preto, SP
dc.description.affiliationFundação Pio XII, Barretos
dc.description.affiliationUnespDepartamento de Biologia UNESP Campus de São do Rio Preto, Rua Cristovão, Colombo 2265, 15054-000 - Sao Jose do Rio Preto
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1240-1245
dc.identifierhttp://www.wjgnet.com/1007-9327/full/v10/i9/1240.htm
dc.identifier.citationWorld Journal of Gastroenterology, v. 10, n. 9, p. 1240-1245, 2004.
dc.identifier.file2-s2.0-4444277920.pdf
dc.identifier.issn1007-9327
dc.identifier.scopus2-s2.0-4444277920
dc.identifier.urihttp://hdl.handle.net/11449/67730
dc.identifier.wosWOS:000208097800003
dc.language.isoeng
dc.relation.ispartofWorld Journal of Gastroenterology
dc.relation.ispartofjcr3.300
dc.relation.ispartofsjr1,409
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectcytochrome P450 2E1
dc.subjectglutathione transferase
dc.subjectadult
dc.subjectaged
dc.subjectBrazil
dc.subjectcancer risk
dc.subjectCaucasian
dc.subjectchronic gastritis
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdisease association
dc.subjectfemale
dc.subjectfrequency analysis
dc.subjectgene deletion
dc.subjectgenetic polymorphism
dc.subjectgenotype
dc.subjectgeographic distribution
dc.subjectHelicobacter infection
dc.subjectHelicobacter pylori
dc.subjecthuman
dc.subjecthypothesis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectNegro
dc.subjectnull allele
dc.subjectpolymerase chain reaction
dc.subjectpopulation research
dc.subjectrestriction fragment length polymorphism
dc.subjectrisk factor
dc.subjectstomach cancer
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCase-Control Studies
dc.subjectChronic Disease
dc.subjectCytochrome P-450 CYP2E1
dc.subjectFemale
dc.subjectGastritis
dc.subjectGenotype
dc.subjectGlutathione Transferase
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Genetic
dc.subjectRisk Factors
dc.subjectStomach Neoplasms
dc.titleGSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian populationen
dc.typeArtigo
dcterms.licensehttp://www.wjgnet.com/1007-9327/bq.asp
dspace.entity.typePublication
unesp.author.lattes2503906319038306[6]
unesp.author.orcid0000-0003-1491-8878[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia - IBILCEpt

Arquivos

Pacote original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
2-s2.0-4444277920.pdf
Tamanho:
148.08 KB
Formato:
Adobe Portable Document Format
Baixar

Coleções

São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas