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Crystallographic structure of PNP from Mycobacterium tuberculosis at 1.9 angstrom resolution

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dc.contributor.authorNolasco, D. O.
dc.contributor.authorCanduri, F.
dc.contributor.authorPereira, J. H.
dc.contributor.authorCortinoz, JR
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.authorOliveira, J. S.
dc.contributor.authorBasso, L. A.
dc.contributor.authorde Azevedo, W. F.
dc.contributor.authorSantos, D. S.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionPontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
dc.date.accessioned2014-05-20T13:54:20Z
dc.date.available2014-05-20T13:54:20Z
dc.date.issued2004-11-12
dc.description.abstractEven being a bacterial purine nucleoside phosphorylase (PNP), which normally shows hexameric folding, the Mycobacterium tuberculosis PNP (MtPNP) resembles the mammalian trimeric structure. The crystal structure of the MtPNP apoenzyme was solved at 1.9 Angstrom resolution. The present work describes the first structure of MtPNP in complex with phosphate. In order to develop new insights into the rational drug design, conformational changes were profoundly analyzed and discussed. Comparisons over the binding sites were specially studied to improve the discussion about the selectivity of potential new drugs. (C) 2004 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUNESP, Programa Posgrad Biofis Mol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUNESP, Inst Biosci, Dept Biol, Lab Struct Biol & Zoochem,CEIS, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationPUCRS, Ctr Pesquisa Biol Mol & Funct, Rede Brasileira Pesquisa TB, BR-90619900 Porto Alegre, RS, Brazil
dc.description.affiliationUnespUNESP, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, Programa Posgrad Biofis Mol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, Inst Biosci, Dept Biol, Lab Struct Biol & Zoochem,CEIS, BR-13506900 Rio Claro, SP, Brazil
dc.format.extent789-794
dc.identifierhttp://dx.doi.org/10.1016/j.bbrc.2004.09.137
dc.identifier.citationBiochemical and Biophysical Research Communications. San Diego: Academic Press Inc. Elsevier B.V., v. 324, n. 2, p. 789-794, 2004.
dc.identifier.doi10.1016/j.bbrc.2004.09.137
dc.identifier.issn0006-291X
dc.identifier.lattes2901888624506535
dc.identifier.urihttp://hdl.handle.net/11449/19413
dc.identifier.wosWOS:000224794000046
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochemical and Biophysical Research Communications
dc.relation.ispartofjcr2.559
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecttuberculosispt
dc.subjectPNPpt
dc.subjectCrystallographypt
dc.subjectapoenzymept
dc.subjectselectivitypt
dc.titleCrystallographic structure of PNP from Mycobacterium tuberculosis at 1.9 angstrom resolutionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes2901888624506535
unesp.author.orcid0000-0003-4971-463X[9]
unesp.author.orcid0000-0001-7931-5475[1]
unesp.author.orcid0000-0002-7363-8211[5]
unesp.author.orcid0000-0003-0903-2407[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentBiologia - IBpt
unesp.departmentFísica - IBILCEpt

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São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas
Rio Claro - IB - Instituto de Biociências