Logotipo do repositório
 

Publicação:
Ascorbic acid potentiates the cytotoxicity of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegnin

Página do item simplificado
dc.contributor.authorKitagawa, Rodrigo R. [UNESP]
dc.contributor.authorda Fonseca, Luiz M. [UNESP]
dc.contributor.authorXimenes, Valdecir F. [UNESP]
dc.contributor.authorKhalil, Najeh M.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorRaddi, Maria Stella G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Estadual Centro Oeste
dc.date.accessioned2014-05-20T13:26:57Z
dc.date.available2014-05-20T13:26:57Z
dc.date.issued2008-08-01
dc.description.abstractThe interaction of ascorbic acid with 5-methoxy-3,4-dehydroxanthomegnin, an 1,4-naphthoquinone, was investigated using the cytotoxic index for McCoy cells by neutral red assay. The synergstic effect was observed when such compounds were added simultaneously, most probably due to hydrogen peroxide being generated by ascorbate - driven 5-methoxy-3,4-dehydroxanthomegnin redox cycling. Incubation of cells in the presence of 5-methoxy-3,4-dehydroxanthomegnin/ascorbic acid/catalase, an enzyme that destroys H(2)O(2), resulted in an increase of cell survival, reinforcing the involvement of hydrogen peroxide generated as an important oxidizing agent that kills McCoy cells. (C) 2008 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias, BR-17033360 Bauru, SP, Brazil
dc.description.affiliationUniv Estadual Centro Oeste, Dept Farm & Bioquim, BR-85040080 Guarapuava, PR, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias, BR-17033360 Bauru, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPADC-UNESP
dc.format.extent2205-2208
dc.identifierhttp://dx.doi.org/10.1016/j.phytochem.2008.05.007
dc.identifier.citationPhytochemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 69, n. 11, p. 2205-2208, 2008.
dc.identifier.doi10.1016/j.phytochem.2008.05.007
dc.identifier.issn0031-9422
dc.identifier.lattes7927877224326837
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/8765
dc.identifier.wosWOS:000258863100016
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofPhytochemistry
dc.relation.ispartofjcr3.186
dc.relation.ispartofsjr1,048
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPaepalanthus latipesen
dc.subjectEriocaulaceaeen
dc.subjectnaphthoquinoneen
dc.subjectascorbic aciden
dc.subjectcytotoxic activityen
dc.subjectantitumor drugen
dc.titleAscorbic acid potentiates the cytotoxicity of the naphthoquinone 5-methoxy-3,4-dehydroxanthomegninen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
dspace.entity.typePublication
unesp.author.lattes7927877224326837
unesp.author.orcid0000-0003-2636-3080[3]
unesp.author.orcid0000-0003-3032-2556[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, São Vicentept
unesp.departmentCiências Biológicas - IBCLPpt

Arquivos

Licença do Pacote

Agora exibindo 1 - 2 de 2
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

São Vicente - IBCLP - Instituto de Biociências